objective(s): in a new approach, following the development in metal oxide chemistry, the ibuprofen as low water soluble nonsteroidal anti-inflammatory drug diffused into synthetic sol-gel derived nano porous g-alumina by an impregnation method in order to increase the solubility and control the drug release in physiological environment. methods: sol-gel method was utilized for the fabrication o...

background: acute drug poisoning remains an important public health problem and represents the second most frequent accidental disease in children. in this study, we identified epidemiological and clinical features of children admitted for acute drug poisoning and related factors associated with suicidal poisoning. methods: we conducted a retrospective study in the department of pediatrics, the...

tuberculosis is an infectious disease caused by mycobacterium tuberculosis and is the primary cause of mortality in the world. m. tuberculosis strains are important intracellular pathogens causing infection in oxygen-rich macrophages in the lungs. the emergence of aids, declined socioeconomic standards and a lessened emphasis on tb control programs have contributed to the disease resurgence. re...

objective(s): in this study, drug loaded electrospun nanofibrous mats were prepared and drug release and mechanism from prepared nanofibers were investigated.  materials and methods: paclitaxel (ptx) loaded polylactic acid (pla) nanofibers were prepared by electrospinning. the effects of process parameters, such as ptx concentration, tip to collector distance, voltage, temperature and flow rate...

background: nowadays, nosocomial infection with multidrug-resistant acinetobacter is an important problem in the world, which is facing wide spectrum antibiotics and hence has become resistant. m aterials and methods: in this study, positive cultures of acinetobacter from one hundred clinical samples in seven hospitals from tehran during 2012-2013 were collected for checking antibiotic suscepti...

introduction cephalic tetanus is a rare form of tetanus, defined as trismus and cranial nerve palsy. it has a mortality rate of 15 - 30%. case presentation the purpose of this case report was to present a case of cephalic tetanus with trismus, a rare form of tetanus, in an intravenous drug abuser. timely diagnosis and management prevented progression into the generalized form and made the patie...

although the conventional therapies have obviously improved the conditions of patients with cancer, some mechanisms of resistance have led scientists to use alternative agents that can penetrate in most solid tumors. furthermore, the success of cancer therapies depends on limiting the uptake of toxins to normal tissues and their selectivity to malignant cells. the involvement of natural and gen...