In recent decades cervical arthroplasty, or cervical disc replacement, has been steadily increasing in popularity as a procedure for the treatment of degenerative pathologies of the cervical spine. This is based on an evolving body of literature that documents superior outcomes in cervical disc replacement over fusion, for both single and double level pathologies, in well selected patients. One...

Pancreatic cancer is highly malignant with limited therapy and a poor prognosis. TRAIL-activating therapy has been promising, however, clinical trials have shown resistance and limited responses of pancreatic cancers. We investigated the effects of calmodulin(CaM) antagonists, trifluoperazine(TFP) and tamoxifen(TMX), on TRA-8-induced apoptosis and tumorigenesis of TRA-8-resistant pancreatic can...

The dynamics of two massive black holes in a rotationally supported nuclear disc of mass Mdisc = 10 8M⊙ is explored using N-Body/SPH simulations. Gas and star particles are co–present in the disc. Described with a Mestel profile, the disc has a vertical support provided by turbulence of the gas, and by stellar velocity dispersion. A primary black hole of mass 4 × 106M⊙ is placed at the centre o...

The death-inducing signaling complex (DISC) initiates death receptor-induced apoptosis. DISC assembly and activation are controlled by c-FLIP isoforms, which function as pro-apoptotic (c-FLIPL only) or anti-apoptotic (c-FLIPL/c-FLIPS) regulators of procaspase-8 activation. Current models assume that c-FLIP directly competes with procaspase-8 for recruitment to FADD. Using a functional reconstit...

We introduce multi-scale filtering by the way of certain double convolution systems. We prove stability theorems for these systems and make connections with function theory in the poly-disc. Finally, we compare the framework developed here with the white noise space framework, within which a similar class of double convolution systems has been defined earlier.

Presently, there are no established treatments to prevent, stop or even retard back pain arising from disc degeneration. Previous studies have shown that Link N can act as a growth factor and stimulate the synthesis of proteoglycans and collagens, in IVD. However, the sequences in Link N involved in modulating cellular activity are not well understood. To determine if disc cells can proteolytic...