Concerns about increasing bacterial resistance to vancomycin, have caused the adult treatment guidelines to recommend higher trough concentrations based on the type and location of infectious disease. Although these recommendations are not specific to children, the values can be extrapolated. This prospective study was designed to evaluate efficacy of current vancomycin dosing recommendations t...

      Many premature neonates suffer from apnea, and aminophylline is administrated for them. The objective of this study was to reveal pharmacokinetic (PK) parameters of theophylline in Iranian premature neonates. Premature neonates (68) who were admitted in the Neonatal Intensive Care Unit (NICU) of Namazi, Hafez, and Zeinabieh Hospitals were included in the study. All of them received 5 mg/k...

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Jeffrey Fudin, PharmD, DAIPM, FCCP, FASHP President and Director, Scientific and Clinical Affairs for Remitigate, LLC, Delmar, NY Adjunct Associate Professor of Pharmacy Practice and Pain Management, Albany College of Pharmacy and Health Sciences, Albany, NY Adjunct Associate Professor, Western New England University College of Pharmacy, Springfield, MA Clinical Pharmacy Specialist and Director...

Gefitinib showed response in phase II clinical trials and with better clinical response in lung cancer with activating mutations in the tyrosine kinase domain of the EGFR. Questions of toxicity and potential dosing regimens impede the use in a prevention setting. This study will provide scientific evidence for the utility of testing and comparing weekly and daily dosing regimens in clinical tri...

PURPOSE Results of a study comparing the performance of allometric versus consensus guideline-recommended vancomycin dosing in achieving initial trough concentrations within the desired range are reported. METHODS A retrospective study was conducted to compare selected outcomes with 2 vancomycin dosing methods: (1) dosing by total body weight, as recommended in current consensus guidelines, a...

DKR Thus far, I am aware of 12 trials that have directly compared split dosing with evening-before dosing for bowel preparation, and all but 1 of these trials found that split dosing was superior with regard to efficacy. None of the trials found evening-before dosing to be superior. In these studies, the benefits of split dosing were particularly evident in the ascending, or right, colon. The m...

OBJECTIVE The recommended dosing frequency of oral penicillin for the treatment of acute streptococcal tonsillopharyngitis has long been 3 to 4 times daily. In 1994, treatment guidelines included twice-daily (BID) dosing for the first time, a recommendation that could significantly increase the ease of compliance. This meta-analysis was performed to determine whether overall cure rates differed...

many premature neonates suffer from apnea, and aminophylline is administrated for them. the objective of this study was to reveal pharmacokinetic (pk) parameters of theophylline in iranian premature neonates. premature neonates (68) who were admitted in the neonatal intensive care unit (nicu) of namazi, hafez, and zeinabieh hospitals were included in the study. all of them received 5 mg/kg amin...

OBJECTIVES Previous studies have examined renal safety of once daily intravenous tobramycin in individuals with cystic fibrosis. This has been mainly in combination with ceftazidime in an adolescent or adult population. In this report, we describe our institutional experience of once daily intravenous tobramycin in combination with a variety of second anti-pseudomonal antibiotics in children wi...