In the last decades, treatment planning for multicatheter interstitial breast brachytherapy has evolved considerably from fluoroscopy-based 2D to anatomy-based 3D planning. To plan the right positions of the catheters, ultrasound or computed tomography (CT) imaging can be used, but the treatment plan is always based on postimplant CT images. With CT imaging, the 3D target volume can be defined ...

A radiobiologically based 3D model of normal tissue has been developed in which complications are generated when 'irradiated'. The aim is to provide insight into the connection between dose-distribution characteristics, different organ architectures and complication rates beyond that obtainable with simple DVH-based analytical NTCP models. In this model the organ consists of a large number of f...

We have studied the accuracy of statistical parameters of dose distributions in brachytherapy using actual clinical implants. These include the mean, minimum and maximum dose values and the variance of the dose distribution inside the PTV (planning target volume), and on the surface of the PTV. These properties have been studied as a function of the number of uniformly distributed sampling poin...

Introduction: The rapid use of computed tomography (CT) scan is of great concern, due to increase in patients’ dose. Optimization of CT protocol is a vital issue in dose reduction. This study aimed to optimize radiation dose in cranial CT and assess modifications in image quality under radiation dose reduction. Material and Methods: A poly(me...

Background: Radiation Pneumonia (RP) is one of the most extensive side effects in Stereotactic Body Radiotherapy (SBRT) of lung cancer. SBRT are performed by means of Intensity Modulated Radiotherapy (IMRT), Intensity Modulated Arc Therapy (IMAT), CyberKnife (CK) or Helical Tomotherapy (HT) treatment methods. In this study, we performed a plan study to determine the plan parameter such as the M...

Introduction: In the treatment of breast cancer, breast conserving surgery (BCS) and whole breast irradiation is a usual technique. The influence of lumpectomy boost following breast radiotherapy is apparent, but there are different delivery methods. This work intended to compare the dosimetric parameters of electron beams and photon beams for boosting irradiation in breast can...

Pharmacokinetics of the investigational cephalosporin ceftriaxone were studied after 30-min intravenous infusions of three ascending single doses of 0.5, 1, and 2 g crossed over in 12 normal subjects. Serially collected plasma and urine samples were analyzed for ceftriaxone by high-performance liquid chromatography. Plasma concentration-time profiles were characterized by a linear two-compartme...

in this study, the effects of siraitia grosvenorii fruits extracts (sgfe) on physical fatigue were investigated. one hundred and forty-four mice were randomly divided into four groups: control group, low-dose sge-treated group, middle-dose sge-treated group and high-dose sgfe-treated group. the animals of control group received an oral administration of physiological saline in a volume of 2.5 m...

objective(s) during recent years, there has been an increasing interest in contribution of environmental pollutants as heavy metals to human male infertility. present study was aimed to investigate the effects of maternal lead acetate exposure during lactation on postnatal development of testis in offspring rats. materials and methods a total of 60 female rats randomly divided into four equal g...

IMRT is a well-known and widely used treatment technique for carcinoma of the prostate (PCa) because it permits dose escalation to tumour while sparing normal tissues. In Sri Lanka, along with IMRT, 3DCRT also in PCa. This study was carried out compare against Simultaneous- Integrated Boost Intensity Modulated Radiation Therapy (SIB-IMRT), Sequential Standard using dosimetric parameters such as...