In epidemiological studies for an environmental risk assessment, doses are often observed with errors. However, they have received little attention in data analysis. This paper studies the effect of measurement errors on the observed dose-response curve. Under the assumptions of the monotone likelihood ratio on errors and a monotone increasing dose-response curve, it is verified that the slope ...

Many current dose-response methods assume a parametric shape of some form and do not accommodate comparisons between methods. Motivated by a need to be able to compare dose-response curves without assuming a parametric shape to the dose-response curve, we applied our technique to model them by non-parametric smoothing methods and also estimate area under the curves. Given that we do not know th...

We show here that recombinant endostatin protein has a biphasic effect on the inhibition of endothelial cell migration in vitro. In tumor-bearing animals, there is a similar biphasic effect on the inhibition of tumor growth and on circulating endothelial cells after once-daily s.c. injections. This biphasic effect is revealed as a U-shaped curve in which efficacy is optimal between very low and...

abstract to study the efficacy of glyphosate and nicosulfuron herbicides on barnyardgrass [echinochloa crus-galii (l.) p. beauv.] and velvetleaf (abotilon theophrasti medicus.) control and to find the ed50 index, experiments were conducted as factorial arrangement of treatments 2×7 based on completely randomized design with six replications for each weed in 2008-9 at research greenhouse, ferdow...

Background: The present study aimed to introduce a rapid transmission dosimetry through an electronic portal-imaging device (EPID) to achieve two-dimensional (2D) dose distribution for homogenous environments. Material and Methods: In this Phantom study, first, the EPID calibration curve and correction coefficients for field size were obtained from EPID and ionization chamber. Second, the...

background rapid dose assessment using biological dosimetry methods is essential to increase the chance of survival of exposed individuals in radiation accidents. objectives we compared the expression levels of the fdxr and rad51 genes at 6 and 18 mv beam energies in human peripheral blood lymphocytes. the results of our study can be used to analyze radiation energy in biological dosimetry. con...