TO THE EDITOR—We read with interest the article by Dalfino et al [1] that evaluated a high-dose extended-interval colistin dosage regimen for critically ill patients. Colistin is experiencing resurgence in use given the rise in multidrug-resistant infections [2]. As a result, studies that provide outcome data to support clinical dosage regimens are valuable. From a safety perspective, the varia...

BACKGROUND Aneurysmal subarachnoid hemorrhage is a significant cause of death and disability. Nimodipine 60 mg administered enterally every 4 h improves neurologic outcomes in these patients. However, hypotension is an adverse effect of nimodipine and is believed to prompt clinicians to prescribe an unproven, nonstandard nimodipine dosing regimen. OBJECTIVES The primary objective was to deter...

The present study was conducted on five healthy male cross bred calves to study the kinetic dispositionand urinary excretion of levofloxacin following its single subcutaneous administration at the dose of4 mg.kg-1. The concentration of levofloxacin in plasma and urine samples was estimated by microbiologicalassay. Peak plasma level of levofloxacin (2.8 ± 0.3 μg.ml-1) was observed at 45 min and ...

INTRODUCTION The effectiveness of vitamin D in reducing falls among long-term care (LTC) seniors remains nonconclusive. We reviewed how vitamin D dosing regimen could affect rate of fall and number of fallers among LTC seniors. METHODS We conducted a systematic literature review. Studies were selected by two independent reviewers based on study characteristics (age 75 or older), quality asses...

AIM To determine the safety, efficacy, and need to measure peak serum vancomycin concentrations in a neonatal population using a standard vancomycin dosage regimen. METHOD A total of 101 infants who were admitted to a regional neonatal intensive care unit and received vancomycin (15 mg/kg every 12 or 18 hours depending on postnatal age) were studied retrospectively. Infants who had been start...

The aim of this study was to determine whether a tapered dosage regimen of paroxetine in pregnant women might be useful to avoid withdrawal syndromes in neonates after delivery. We characterized the transplacental transfer of paroxetine in perfused human placenta, fitting a pharmacokinetic model to the results and applying the model and parameters to evaluate a tapered dosage regimen. Paroxetin...