ceutical dosage forms. They serve as carriers for drugs that are topically delivered by way of the skin, cornea, rectal tissue, nasal mucosa, vagina, buccal tissue, urethral membrane, and external ear lining (1). Because of their peculiar rheological behavior, semisolids can adhere to the application surface for sufficiently long periods before they are washed off. This property helps prolong d...

X-ray microtomography has great potential for improving the understanding of the structural features of solid dosage forms and the changes in those features during manufacturing, handling, and storage. This article describes the basic principles of the technique and provides examples of its potential applications. harmaceutical scientists have long sought the ability to see inside the solid dos...

Lubrication plays a key role in successful manufacturing of pharmaceutical solid dosage forms; lubricants are essential ingredients in robust formulations to achieve this. Although many failures in pharmaceutical manufacturing operations are caused by issues related to lubrication, in general, lubricants do not gain adequate attention in the development of pharmaceutical formulations. In this p...

The present paper describes the utilization of high-pressure liquid chromatography for determination of Chlorhexidine in complex samples of dosage forms. Chromatographic separation was performed on a cyanopropyl column using acetate buffer in the mixture of water and acetonitrile ((pT = 2:3) as the mobile phase. The linear dependence of the peak size on concentration of Chlorhexidine in the ran...

a simple and sensitive high performance liquid chromatographic method with electrochemical detection is described for the quantitative determination of the amoxycillin and clavulanic acid in pharmaceutical dosage forms. separation of sample components occurs on a reversed phase c18 column with a mobile phase consisting of methanol-water-phosphate buffer. for the amperometric detection, the pote...