Abstract Phosphatidylinositol 4-phosphate 5-kinase type 1 gamma (Pip5k1c) generates phosphatidylinositol 4,5-bisphosphate, also known as PI(4,5)P2 or PIP2. Many pronociceptive signaling pathways and receptor tyrosine kinases signal via PIP2 hydrolysis. Previously, we found that pain signaling and pain sensitization were reduced in Pip5k1cþ/ global heterozygous knockout mice. Here, we sought to ...

UNLABELLED To evaluate the hyperalgesia and histological abnormalities induced by contact between the dorsal root ganglion and the nucleus pulposus. METHODS Twenty Wistar rats were used, divided into two experimental groups. In one of the groups, a fragment of autologous nucleus pulposus was removed from the sacrococcygeal region and deposited on the L5 dorsal root ganglia. In the other group...

Paclitaxel is an antineoplastic drug, and its usage is often limited by severe peripheral polyneuropathy characterized by symptoms in remote extremities. It is suggested that subpopulations of dorsal root ganglion (DRG) neurons are impacted functionally and/or structurally. In this study, the neurotoxic effect of this drug in cultured rat DRG neurons was analyzed by measuring their neurite leng...

The compound action potential of the unmedullated fibers arising from dorsal root ganglia, as recorded in cat skin nerves after conduction of simultaneously initiated impulses, shows among its components a temporal dispersion corresponding to velocities between 2.3 and 0.7 M.P.S. The maximum representation of the component velocities is at about 1.2 M.P.S. On both sides of the maximum the repre...

7 8 Neuroscience and Mental Health Institute and Department of Pharmacology or Physiology 9 Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada T6G 2H7, 10 11 12 Manuscript properties: 10 Figures; 2 Tables; Abstract 245 words; 13 14 15 Running Header: Neuron type specific actions of gabapentinoids 16 17 18 Corresponding author: 19 20 P.A. Smith, 21 Department of Pharmacol...

The segmented trunk peripheral nervous system is generated by ventrally migrating neural crest cells that exclusively invade the anterior sclerotome and differentiate into metameric dorsal root and sympathetic ganglia. Meanwhile, ventral spinal motor axons also project through the somites in a segmental fashion. How peripheral nervous system segmentation is generated is unknown. We previously s...