Differences in the composition and subcellular localization of heteroreceptors brain can trigger central nervous system diseases, including epilepsy autism. Protein-protein interactions between Dopamine Receptors (DRs) GLUN2A GLUN2B subunits are critical mechanisms that regulate dopamine glutamate coordinated signals. These may be involved pathophysiological predisposition epilepsy. We hypothes...

The dopamine receptors have been classified into two groups, the D1like and D2-like dopamine receptors, respectively, based on molecular biology and pharmacological studies. The D1-like dopamine receptors comprise the D1 and D5 dopamine receptors and the D2-like dopamine receptors include the D2, D3 and D4 dopamine receptors. The gene structures of these two classes of receptors are dissimilar ...

In vivo administration or in vitro application of dopamine or of dopamine receptor agonists induce vasodilatation in the cerebral, coronary, renal and mesenteric vascular beds and cause hypotension. Moreover, dopamine stimulates cardiac contractility and induces diuresis and natriuresis. Peripheral (cardiovascular and renal) dopamine receptors belong to the D1-like and D2-like receptor superfam...

Introduction: Dopamine plays an important role in the central nervous system for modulating food intake. Dopamine receptors are distributed within the hypothalamus, and expression of D1 receptors is significant in hypothalamic paraventricular nucleus (PVN). Therefore, the aim of this study was to find if PVN-microinjected SKF38393, D1 receptor agonist, may modulate food intake. Methods: Gui...

the mesolimbic dopamine (da) system contains both d1-like and d2-like receptors, has been connected to control of locomotor behavior. an apparent role for d1 and d2 receptors throughout the mesolimbic system in the alteration of locomotor behavior has been demonstrated in pharmacological studies. the nucleus accumbens (nac) is comprised of a core and a shell subregion, which is a component of t...

introduction: the protective and antisecretory effects of dopamine agonists on the stomach have been already reported, but the effect of bromocriptine (d2 dopamine agonist) on histamine stimulated gastric acid secretion (gas) needs to be investigated. methods: for gastric sampling, animals were anesthetized and a polyethylen tube was introduced into the stomach through esophagus. a cannula was ...

The non-catechol, selective dopamine D2-agonist compound 3H-205-502 was used to localize dopamine D2 receptors by autoradiography after in vitro labeling of brain sections. The characteristics of the binding of this ligand to tissue sections were those expected from the labeling of dopamine D2 receptors. The binding of 3H-205-502 was inhibited selectively and stereospecifically by dopamine D2 a...

Catecholamines play an important regulatory role in cutaneous wound healing. The exact role of dopamine in human epidermis has yet to be fully elucidated. Current published evidence describes its differential effects on two separate families of G protein coupled receptors: D1-like and D2-like dopamine receptors. Dopamine may enhance angiogenesis and wound healing through its action on dopamine ...

A facile strategy of stepwise molding of a ribonucleopeptide (RNP) complex affords fluorescent RNP sensors with selective dopamine recognition. In vitro selection of a RNA-derived RNP library, a complex of the Rev peptide and its binding site Rev Responsive Element (RRE) RNA appended with random nucleotides in variable lengths, afforded RNP receptors specific for dopamine. The modular structure...