in this study, the influence of dopamine receptor agonists and antagonists on antinociception induced by bac10fen has been examined in the formalin test. the gaba-b agonist bac10fen induced antinociception in both phases of the formalin test in mice. the dopamine receptor agonists skf 38393 and quinpirole also induced antinociception in both phases of the test. skf 38393 but not quinpirole pote...

Dopamine signals through D1-like and D2-like receptors, which can stimulate or inhibit, respectively, neuronal activity. Here we assessed the balance between D1 or D2 receptor signaling in the human brain and how it is affected in alcoholism. Using PET, we measured the relationship between changes in dopamine and brain glucose metabolism induced by methylphenidate in controls and alcoholics. We...

Synthetic biology has significantly advanced the design of synthetic trigger-controlled devices that can reprogram mammalian cells to interface with complex metabolic activities. In the brain, the neurotransmitter dopamine coordinates communication with target neurons via a set of dopamine receptors that control behavior associated with reward-driven learning. This dopamine transmission has rec...

[This corrects the article DOI: 10.1186/1758-5996-6-104.].

OBJECTIVE Dopamine mediates the rewarding effects of food that can lead to overeating and obesity, which then trigger metabolic neuroadaptations that further perpetuate excessive food consumption. We tested the hypothesis that the dopamine response to calorie intake (independent of palatability) in striatal brain regions is attenuated with increases in weight. METHOD We used positron emission...

there is interrelationship between the immune and nervous systems that is accomplished by the molecular mediators. dopamine is one of the most important neurotransmitters. five different dopamine receptor genes (drd1, drd2, drd3, drd4, and drd5) have been recognized and cloned. the expression of the dopamine receptors is well characterized in the brain but little work has been done to examine t...

STUDY OBJECTIVE To compare the ability of dopamine and norepinephrine to reverse hemodynamic and metabolic abnormalities of human hyperdynamic septic shock. DESIGN Prospective, double-blind, randomized trial. SETTING An ICU in a university hospital. PATIENTS Adult patients with hyperdynamic septic shock after fluid resuscitation. INTERVENTIONS Patients were assigned to receive either do...

The rates of metabolic diseases, such as type 2 diabetes mellitus (T2DM), obesity, and cardiovascular disease (CVD), markedly increase with age. In recent years, studies have reported an association between metabolic changes and various pathophysiological mechanisms in the central nervous system (CNS) in patients with metabolic diseases. Oxidative stress and hyperglycemia in metabolic diseases ...