Stimulation of dopamine D1 receptors has profound effects on addictive behavior, movement control, and working memory. Many of these functions depend on dopaminergic systems in the striatum and D1-D2 dopamine receptor synergies have been implicated as well. We show here that deletion of the D1 dopamine receptor produces a neural phenotype in which amphetamine and cocaine, two addictive psychomo...

Catecholamines play an important regulatory role in cutaneous wound healing. The exact role of dopamine in human epidermis has yet to be fully elucidated. Current published evidence describes its differential effects on two separate families of G protein coupled receptors: D1-like and D2-like dopamine receptors. Dopamine may enhance angiogenesis and wound healing through its action on dopamine ...

introduction: the protective and antisecretory effects of dopamine agonists on the stomach have been already reported, but the effect of bromocriptine (d2 dopamine agonist) on histamine stimulated gastric acid secretion (gas) needs to be investigated. methods: for gastric sampling, animals were anesthetized and a polyethylen tube was introduced into the stomach through esophagus. a cannula was ...

BACKGROUND Food addiction is a debated topic in neuroscience. Evidence suggests diabetes is related to reduced basal dopamine levels in the nucleus accumbens, similar to persons with drug addiction. It is unknown whether insulin sensitivity is related to endogenous dopamine levels in the ventral striatum of humans. We examined this using the agonist dopamine D2/3 receptor radiotracer [(11)C]-(+...

The dopamine receptors have been classified into two groups, the D1like and D2-like dopamine receptors, respectively, based on molecular biology and pharmacological studies. The D1-like dopamine receptors comprise the D1 and D5 dopamine receptors and the D2-like dopamine receptors include the D2, D3 and D4 dopamine receptors. The gene structures of these two classes of receptors are dissimilar ...

We identified protein 4.1N as a D2-like dopamine receptor-interacting protein in a yeast two-hybrid screen. Protein 4.1N is a neuronally enriched member of the 4.1 family of cytoskeletal proteins, which also includes protein 4.1R of erythrocytes and the 4.1G and 4.1B isoforms. The interaction of protein 4.1N was specific for the D2 and D3 dopamine receptors and was independently confirmed in pu...

Schizophrenia is a severe disorder of personality which has a genetic basis. Schizophrenia arises from a change in brain development. There is no strong evidence that disturbances in neurotransmitter systems are a primary cause. Anti-psychotic drugs act primarily through D2 and D3 dopamine receptors. The atypical drug clozapine may act through a number of different receptors, including D2, D3 a...

Previous pharmacological studies have implicated dopamine as a modulator of olfactory bulb processing. Several disorders characterized by altered dopamine homeostasis in olfaction-related brain regions display olfactory deficits. To further characterize the role of dopamine in olfactory processing, we subjected dopamine transporter knockout mice (DAT -/-) and dopamine receptor 2 knockout mice (...

Dopaminergic signaling within the basal ganglia has classically been thought to occur within two distinct neuronal pathways; the direct striatonigral pathway which contains the dopamine D1 receptor and the neuropeptides dynorphin (DYN) and substance P, and the indirect striatopallidal pathway which expresses the dopamine D2 receptor and enkephalin (ENK). A number of studies have also shown, how...

Introduction & Objective: Male fertility depends on the proper function of a complex system of organs. Harmful effects of morphine on male reproduction and fertility are well documented. Dopamine facilitates sexual behavior in different animal species. The antagonizing of dopamine D2 receptors with sulpiride was aimed to investigate the interaction of dopaminergic system with morphine-induced i...