Sodium tungstate has been found to correct hyperglycemia in insulin- and noninsulin-dependent models of diabetes when administered in drinking fluid with a low degree of toxicity; thus, it provides a potential treatment for diabetes. In the present report, pharmacokinetic studies with sodium tungstate were carried out in the Sprague-Dawley rat and beagle dog. This drug was administered either i...

The leopard (Panthera pardus) as an adaptable felid widely distributed in varied ecosystems of Iran. The Golestan Natural Park is one of the main habitats of leopard in the country. It has divers diet and preying various types of preys such as wild ungulate and livestock. The prey remains’ samples of leopard were collected and preserved using ethanol 96% and whole genomic DNA was extracted. The...

Larger dog breeds live shorter than the smaller ones, opposite of the mass-lifespan relationship observed across mammalian species. Here we use data from 90 dog breeds and a theoretical model based on the first principles of energy conservation and life history tradeoffs to explain the negative correlation between longevity and body size in dogs. We found that the birth/adult mass ratio of dogs...

The aim of this study was to report a new cause of cataract, namely snake bite induced cataract in a dog. A 3-year-old male mongrel dog was referred to our clinic for the assessment of cataract in both eyes. The dog was bitten by a snake nearly 4 months ago. A 40 dioptre acrylic lens with 13 mm haptics was implanted into the lens capsule. In the left eye, posterior synechia was detected in the ...

Dogs are relinquished to shelters due to behavioral problems, such as leash pulling and jumping up. Interomones are chemical cues produced by one species that elicit a response in a different species. We reported earlier that androstenone, a swine sex pheromone, acts as an interomone to reduce barking in dogs. Here we report two models using 10 dogs/study: a dog jumping and a dog walking model....

Synopsis In recent years there has been growing interest in uncovering evolutionary and lifetime factors that may contribute to the domestic dog’s (Canis lupus familiaris) success anthropogenic environments. The readiness with which dogs form social attachments, their hyper-social focus, flexibility have all areas of investigation. Prior research demonstrated many pet infant-caregiver type atta...

Short-term variability (STV), to quantify beat-to-beat variability of repolarization, is a surrogate parameter that reliably identifies proarrhythmic risk in preclinical models. Examples include not only the use in the chronic atrioventricular block (CAVB) dog model whereby it was developed but also in vulnerable patients with heart failure or drug-induced long QT syndrome. In the CAVB dog mode...

The objective of this paper is to report evaluated observations from survey records captured through a cross-sectional observational study regarding canine populations and dog owners in rabies enzootic KwaZulu-Natal province, South Africa. Our aim was to evaluate respondent knowledge of canine rabies and response to dog bite incidents towards improved rabies control. Six communities consisting ...