Four whole-lake inorganic C addition experiments were conducted in lakes of differing trophic status. Inorganic C addition enriched algal carbon in C and changed the C-DOC by +1.5& to +9.5&, depending on the specific lake. This change in C-DOC represented a significant input of algal DOC that was not completely consumed by bacteria. We modeled the dynamics in C-DOC to estimate the fluxes of alg...

12 [1] We investigated how the source and chemical character of aquatic dissolved organic 13 carbon (DOC) change over the course of the runoff season (May–November, 1999) in 14 Green Lakes Valley, a high-elevation ecosystem in the Front Range of the Colorado Rocky 15 Mountains. Samples were collected on North Boulder Creek from four sites across an 16 alpine/subalpine ecotone in order to unders...

In this work, a semimechanistic pharmacokinetic/pharmacodynamic (PK/PD) model to quantitatively describe the antitumor activity of docetaxel (Doc) and cabozantinib (Cab) under monotherapy, concurrent therapy, interval therapy, and different sequential therapy in mouse xenograft models of castration-resistant prostate cancer was developed and evaluated. The pharmacokinetics (PK) of Doc and Cab w...

Deoxycorticosterone salt (DOC-salt) hypertension-induced renal damage is enhanced in α-calcitonin gene-related peptide (α-CGRP) knockout (KO) compared with wild-type (WT) mice. However, since the α-CGRP KO mice have a 15-20 mmHg higher baseline mean arterial pressure (MAP) than WT mice, they also have a higher MAP than WT mice throughout the course of DOC-salt hypertension. To determine the mec...

PURPOSE Although the combination of Adriamycin (ADR) and docetaxel (DOC) showed a better cure rate against metastatic breast cancer in a clinical study, severe myelosuppression and cardiotoxicity were dose-limiting factors. The purpose of this study was to establish the most suitable dosing schedule to relieve severe adverse effects and improve the antitumor effects. EXPERIMENTAL DESIGN Both ...

[1] An evaluation of DOC export with the formation of North Pacific Intermediate Water is presented. Data from sites representing the relevant North Pacific water masses (subtropical, subpolar, and subtropical transitional) are used to demonstrate the process. We suggest that dissolved organic carbon (DOC)-replete Oyashio (subpolar) water mixes with DOC-depleted Kuroshio (subtropical) water in ...

In vitro differentiation of mesenchymal stromal cells (MSC) into osteocytes (human differentiated osteogenic cells, hDOC) before implantation has been proposed to optimize bone regeneration. However, a deep characterization of the immunological properties of DOC, including their effect on dendritic cell (DC) function, is not available. DOC can be used either as cellular suspension (detached, De...

Scott and Smith (1969) develop estimators for linear functions from a two stage cluster sample, with their discussion repeated in many places. This discussion was reviewed in c01ed13.doc. It is note-worthy that Scott and Smith allow expressions for the variance to depend on the cluster. A similar development is given by Vallient et al.. We repeated the derivation of Vallient et al using the fin...

Temporal variation in dissolved organic carbon (DOC) and water color (light absorption at 440 nm) was measured in 20 lakes in northern Michigan that varied in DOC, pH, morphometry, and relative productivity as indicated by chlorophyll and total phosphorus (TP). Monthly observations during May–August over 6 yr revealed that DOC and color varied by 6and 28-fold among lakes and varied substantiall...

Light-absorbing dissolved organic carbon (DOC) constitutes a major part of the organic carbon in glacierized regions, and has important influences on the carbon cycle and radiative forcing of glaciers. However, few DOC data are currently available from the glacierized regions of the Tibetan Plateau (TP). In this study, DOC characteristics of a mediumsized valley glacier (Laohugou Glacier No. 12...