نتایج جستجو برای: dna profiling
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Evidence suggests that epigenetic perturbations are involved in the adverse effects associated with some drugs and toxicants, including certain classes of non-genotoxic carcinogens. Such epigenetic changes (altered DNA methylation and covalent histone modifications) may take place at the earliest stages of carcinogenesis and their identification holds great promise for biomedical research. Here...
In recent years, forensic mRNA profiling has increasingly been used to identify the origin of human body fluids. By now, several laboratories have implemented and also use it in criminal casework. 2018 FoRNAP (Forensic RNA Profiling) group was established among a number these with aim sharing experiences, discussing optimization potential, identifying challenges suggesting solutions regards To ...
The discovery of hypervariable minisatellite deoxyribonucleic acid (DNA) by Jeffreys and co-workers in 1985 provided forensic scientists with a means of discriminating between individuals that was many orders of magnitude greater than the traditional methods used before that date. Probably themost important forensic application of DNA profiling is in the identification of rapists. The original ...
In last few years, DNA analysis methods are applied to forensic cases. Forensic dental record comparison has been used for human identification in cases where destruction of bodily tissues or prolonged exposure to the environment has made other means of identification impractical, i.e., after fire exposure or mass disaster.Teeth play an important role in identification and criminology, due to t...
DNA chips and microarrays have been used to simultaneously analyze the expression profiling of many genes [1, 2]. In the analysis, the two-color method [3] is generally employed to determine the relative expression levels between two samples. However, not only the relative expression levels between target genes in a sample but also the absolute expression level of each target gene in a sample c...
Background: Isocitrate dehydrogenase (IDH) mutation status is a key diagnostic and prognostic feature of gliomas. There are conflicting reports regarding the stability IDH mutations throughout glioma evolution treatment. Here, we provide an institutional experience patients with longitudinally in order to determine if changes over time. Methods: We retrospectively identified from 2009-2018 immu...
The profiling of gene expression patterns with DNA microarrays is recently being widely used not only in basic molecular biological studies but also in the practical fields. In clinical application, for example, this technique is expected to be quite useful in making a correct diagnosis. In the pharmacological area, the microarray analysis can be applied to drug discovery and individualized dru...
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