نتایج جستجو برای: dna methyltransferase

تعداد نتایج: 521977  

Journal: :Oncogene 2004

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Journal: :Nucleic Acids Research 1993

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Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2011

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Journal: :Journal of Biological Chemistry 2003

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Journal: :International Journal of Cancer 1999

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Journal: :Journal of Biological Chemistry 2004

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Journal: :Proceedings of the National Academy of Sciences 2005

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Journal: :Journal of Biological Chemistry 1999

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Journal: :Carcinogenesis 2011
Flora Chik Moshe Szyf

A hallmark of cancer is aberrant DNA methylation, consisting of global hypomethylation and regional hypermethylation of tumor suppressor genes. DNA methyltransferase inhibitors have been recognized as promising candidate anticancer drugs. Drug development has focused on DNA methylation inhibitors with the goal of activating tumor suppressor genes silenced by DNA methylation. 5-azacytidine (5-AC...

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Journal: :Arthritis and rheumatism 2004
Kurt Oelke Qianjin Lu Derek Richardson Ailing Wu Chun Deng Samir Hanash Bruce Richardson

OBJECTIVE Generalized DNA hypomethylation contributes to altered T cell function and gene expression in systemic lupus erythematosus (SLE). Some of the overexpressed genes participate in the disease process, but the full repertoire of genes affected is unknown. Methylation-sensitive T cell genes were identified by treating T cells with the DNA methyltransferase inhibitor 5-azacytidine and compa...

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