نتایج جستجو برای: dna واکسن e7

تعداد نتایج: 511899  

Journal: :modares journal of medical sciences: pathobiology 2008
azam bolhasani mohammad taghikhani nahid ghasemi hooriyeh soleimanjahi sima rafati

objective: dna vaccines have been widely used to develop immunity against various pathogens including parasites and viruses. the potential of dna vaccine to induce an effective immune response is related to the expression levels of the encoded protein in eukaryotic cells. therefore, optimization of plasmid dna delivery system is a major concern in protein expression in order to make an efficien...

Journal: :Cancer research 2012
Caihua Liang Carmen J Marsit Michael D McClean Heather H Nelson Brock C Christensen Robert I Haddad John R Clark Richard O Wein Gregory A Grillone E Andres Houseman Gordana Halec Tim Waterboer Michael Pawlita Jeffrey F Krane Karl T Kelsey

Human papillomavirus (HPV) is an accepted cause of head and neck squamous cell carcinoma (HNSCC), and patients with HPV-associated HNSCC have a favorable prognosis. Currently, there is no general guidance on the most appropriate biomarkers for clinical assessment of HPV in these malignancies. We compared PCR-based and serologic HPV assays, as well as p16 immunohistochemistry, individually and i...

Journal: :Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000
W M Chien J N Parker D C Schmidt-Grimminger T R Broker L T Chow

The human papillomavirus type 18 E7 protein subverts the pRb/E2F pathway to promote S-phase reentry by postmitotic, differentiated primary human keratinocytes in support of viral DNA amplification. We prepared a panel of HPV-18 E7 mutations in pRb binding or in casein kinase II (CKII) phosphorylation. Our results showed that the ability of E7 binding to pRb correlated with the activation of DNA...

2017
Paola Di Bonito Chiara Chiozzini Claudia Arenaccio Simona Anticoli Francesco Manfredi Eleonora Olivetta Flavia Ferrantelli Emiliana Falcone Anna Ruggieri Maurizio Federico

We recently proved that exosomes engineered in vitro to deliver high amounts of HPV E7 upon fusion with the Nefmut exosome-anchoring protein elicit an efficient anti-E7 cytotoxic T lymphocyte immune response. However, in view of a potential clinic application of this finding, our exosome-based immunization strategy was faced with possible technical difficulties including industrial manufacturin...

Journal: :Journal of virology 2002
Regina B Park Elliot J Androphy

Papillomaviruses possess small DNA genomes that encode five early (E) proteins. Transient DNA replication requires activities of the E1 and E2 proteins and a DNA segment containing their binding sites. The E6 and E7 proteins of cancer-associated human papillomavirus (HPV) transform cells in culture. Recent reports have shown that E6 and E7 are necessary for episomal maintenance of HPV in primar...

Journal: :iranian red crescent medical journal 0
ebrahim faghihloo department of virology, school of public health, tehran university of medical sciences, tehran, ir iran majid sadeghizadeh department of genetics, faculty of biological sciences, tarbiat modares university, tehran, ir iran shohreh shahmahmoodi department of virology, school of public health, tehran university of medical sciences, tehran, ir iran talat mokhtari-azad department of virology, school of public health, tehran university of medical sciences, tehran, ir iran; department of virology, school of public health, tehran university of medical sciences, tehran, ir iran. tel/fax: +98-2188962343

results hpv-16 e6 and e7 proteins reduced e-cadherin expression 3.7 and 2.2 times when compared with control cells (p = 0.0221 and p = 0.0461, respectively). this reduction was greater in hpv-16 e6-expressing cells than in hpv-16 e7-expressing cells. although hpv-16 e6 and e7 increased dna methyltransferase 1 expression 2.6 and 3.4 times, respectively (p = 0.0133 and p = 0.0113) when compared w...

Journal: :Journal of immunotherapy 2010
Jae Yeo Park Dong-Hoon Jin Chang-Min Lee Min Ja Jang Sun Young Lee Hyo Seon Shin Yoon Hee Chung Kyung Yong Kim Sung Su Kim Won Bok Lee Yong Kyoo Shin Wang Jae Lee Yeong-Min Park Daejin Kim

The requirement for CD4 T cells in priming and maintaining cytotoxic T-lymphocyte responses presents a long-standing paradox in cellular immunology. In this study, we used sequential coadministration of a DNA vaccine encoding an invariant (Ii) chain in which the class II-associated Ii-peptide region is replaced with CD4 T-helper epitope, PADRE [Pan human leukocyte antigen-DR reactive epitope (I...

Journal: :Vaccine 2009
Jian Yan Dawn K Reichenbach Natasha Corbitt David A Hokey Mathura P Ramanathan Kibwei A McKinney David B Weiner Duane Sewell

Human papillomavirus type 16 (HPV-16) infection is associated with a majority of cervical cancers and a significant proportion of head and neck cancers. Here, we describe a novel-engineered DNA vaccine that encodes a HPV-16 consensus E6/E7 fusion gene (pConE6E7) with the goal of increasing its antitumor cellular immunity. Compared to an early stage HPV-16 E7 DNA vaccine (pE7), this construct wa...

Journal: :Brazilian Journal of Oral Sciences 2022

Aim: Head and Neck Squamous Cell Carcinoma (HNSCC) is a global health problem whose incidence varies by geographic region race according to risk factors. Human papillomavirus (HPV) infection significant factor for HNSCC. HPV-16 HPV-18 are two forms of HPV that carcinogenic. HNSCCs positive have better prognosis rather than negative. The purpose this research was characterize HPV-16, -18 variati...

2011
Azam Bolhassani Elham Mohit Nahid Ghasemi Maryam Salehi Mohammad Taghikhani Sima Rafati

Human papillomaviruses (HPVs) are responsible for an enormous global burden of genital disease. HPV is annually associated with 500,000 new cases of cervical cancer and 250,000 cervical cancer deaths worldwide. There are more than 130 HPV genotypes that have been recognized from various clinical lesions. HPV types 16 and 18 are found in the majority of cervical cancer cases. The association bet...

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