DNA methylation reprogramming (DMR) during preimplantation development erases differentiation-associated, unessential epigenetic information accumulated during gametogenesis, and ultimately brings pluripotency to the resulting embryo. Two patterns of DMR of sperm-derived pronucleus have been reported in mammals. In the first, the male pronucleus is actively demethylated whereas in the second, t...

We have developed a next generation, miniaturized platform to diagnose disease at the point-of-care using diagnostic magnetic resonance (DMR-3). Utilizing a rapidly growing library of functionalized magnetic nanoparticles, DMR has previously been demonstrated as a versatile tool to quantitatively and rapidly detect disease biomarkers in unprocessed biological samples. A major hurdle for bringin...

Tyrosine kinase inhibitors (TKI) improve the prognosis of patients with chronic myelogenous leukemia (CML) by inducing substantial deep molecular responses (DMR); some patients have successfully discontinued TKI therapy after maintaining DMR for ≥1 year. In this cessation study, we investigated the optimal conditions for dasatinib discontinuation in patients who maintained DMR for ≥2 years. Thi...

The popular screening method for urotensin (UT) receptor antagonists is to measure the intracellular calcium concentration with a calcium-sensitive fluorescent dye. This assay format has an inherent limitation on the problem related to the fluorescence interference as it involves fluorescent dyes. In the present study, a label-free assay for the screening of UT receptor antagonists was develope...

Accurate soil moisture content measurements are vital to precision irrigation management. Remote sensing using the microwave spectrum (such as GPS signals) has been used for measuring large area soil moisture contents. In our previous work, we estimated surface soil moisture contents for bare soil using a GPS Delay Mapping Receiver (DMR) developed by NASA. However, the effect of vegetation was ...

The metabolic costs of foraging and the management of O2 and CO2 stores during breath-hold diving was investigated in three female Steller sea lions (Eumetopias jubatus) trained to dive between 10 and 50 m (N=1142 dives). Each trial consisted of two to eight dives separated by surface intervals that were determined by the sea lion (spontaneous trials) or by the researcher (conditioned trials). ...

Background: To investigate if aberrant methylation and expression of imprinted genes of the Igf2-H19 locus in the spermatozoa and embryos could be a paternal epigenetic factor involved in early embryo loss To elucidate the role of estrogen in acquisition of the imprinting at the Igf2-H19 locus during spermatogenesis Materials and Methods: Adult male rats of Holtzman strain were administered tam...

Recent studies suggest that the softerror rate in microprocessor logic is likely to become a serious reliability concern by 2010. Detecting soft errors in the processor’s core logic presents a new challenge beyond what error-detecting and correcting codes can handle. Currently, commercial microprocessor systems that require an assurance of reliability employ an error-detection scheme based on d...

Owing to the unprecedented COVID-19 pandemic, pharmaceutical industry has attracted considerable attention, spurred by widespread expectation of vaccine development. In this study, we collect relevant topics from news articles related and explore their links with two South Korean indices, Drug Medicine index Korea Composite Stock Price Index (KOSPI) Securities Dealers Automated Quotations (KOSD...