نتایج جستجو برای: dlbcl

تعداد نتایج: 2906  

2018
A L F V Assumpção P C Jark C C Hong Z Lu H M Ruetten C M Heaton M E Pinkerton X Pan

BACKGROUND The Janus Kinase (JAK) and Signal Transducer and Activator of Transcription (STAT) pathways play important roles in the pathogenesis of diffuse large B cell lymphoma (DLBCL) in humans, and up-regulated STAT3 expression and activity are associated with worse clinical outcome in humans. No studies have evaluated the JAK-STAT signaling pathway in DLBCL of dogs. HYPOTHESIS STAT3 pathwa...

Journal: :International journal of clinical and experimental medicine 2015
Cheng Fang Danxia Zhu Huajie Dong Mei Ji Jun Wu Xiaoli Xu Gui Cheng Changping Wu Jingting Jiang

Lenalidomide has been shown to produce durable responses in patients with relapsed or refractory diffuse large B cell lymphoma (DLBCL). In order to gain better understanding of the efficacy of lenalidomide and compared the difference in clinical outcome between two subtypes of DLBCL. Seven eligible trials involving 375 adult patients were included in this meta-analysis. The patients in non-germ...

2016
Randy Gascoyne Jung Yong Hong Cheolwon Suh Won Seog Kim

Various strategies have been implemented to improve the outcomes of diffuse large B-cell lymphoma (DLBCL). In recent years, remarkable advances have been achieved, based on the discovery of cell-of-origin in DLBCL and on more effective targeted agents. This commentary will summarize recent updates on the evolution of frontline therapies for DLBCL, focusing on the upcoming promising frontline ch...

2017
Wei-Jie Zhong Xin Xu Zhi-Gang Zhu Qing-Hua Du Hong Du Li Yang Yan-Ying Ling Hua-Bao Xiong Qing-Shan Li

The immunological pathogenesis of diffuse large B cell lymphoma (DLBCL) remains elusive. Searching for new prognostic markers of DLBCL is a crucial focal point for clinical scientists. The aim of the present study was to examine the prognostic value of interferon regulatory factor 8 (IRF8) expression and its effect on the development of Th17 cells in the tumor microenvironment of DLBCL patients...

2017
Su Yao Fangping Xu Yu Chen Yan Ge Fen Zhang Huijie Huang Li Li Danyi Lin Xinlan Luo Jie Xu Donglan Luo Xiaolan Zhu Yanhui Liu

BACKGROUND The ubiquitin-ligase Fbw7 acts as a tumor suppressor, targeting lots of proto-oncogenes for proteolysis. However, the exact role of Fbw7 in diffuse large B-cell lymphoma (DLBCL) development remains unclear. METHODS We evaluated Fbw7 expression in patient samples of DLBCL using immunohistochemical staining. The effect of Fbw7 overexpression on cell viability and apoptosis was invest...

2014
Ai Sato Naoya Nakamura Minoru Kojima Ken Ohmachi Joaquim Carreras Yara Yukie Kikuti Hiroki Numata Daisuke Ohgiya Kei Tazume Jun Amaki Makiko Moriuchi Mitsuki Miyamoto Yasuyuki Aoyama Hidetsugu Kawai Akifumi Ichiki Ryujiro Hara Hiroshi Kawada Yoshiaki Ogawa Kiyoshi Ando

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of malignant lymphoma. The incidence of Epstein-Barr virus (EBV)-positive DLBCL in Asian and Latin American countries ranges from 8 to 10%. The prognosis of patients with EBV-positive DLBCL is controversial. To compare the clinical outcome of EBV-positive and EBV-negative patients with DLBCL in the rituximab era, we analyzed 239 p...

2016
Jung Yong Hong Cheolwon Suh Won Seog Kim

Various strategies have been implemented to improve the outcomes of diffuse large B-cell lymphoma (DLBCL). In recent years, remarkable advances have been achieved, based on the discovery of cell-of-origin in DLBCL and on more effective targeted agents. This commentary will summarize recent updates on the evolution of frontline therapies for DLBCL, focusing on the upcoming promising frontline ch...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Joseph D Dekker Daechan Park Arthur L Shaffer Holger Kohlhammer Wei Deng Bum-Kyu Lee Gregory C Ippolito George Georgiou Vishwanath R Iyer Louis M Staudt Haley O Tucker

High expression of the forkhead box P1 (FOXP1) transcription factor distinguishes the aggressive activated B cell (ABC) diffuse large B-cell lymphoma (DLBCL) subtype from the better prognosis germinal center B-cell (GCB)-DLBCL subtype and is highly correlated with poor outcomes. A genetic or functional role for FOXP1 in lymphomagenesis, however, remains unknown. Here, we report that sustained F...

2011
Masayuki Shiseki Akihiro Masuda Norimichi Watanabe Masami Fujii Tomofumi Kimura Kentaro Yoshinaga Naoki Mori Masanao Teramura Toshiko Motoji

Waldenström's macroglobulinemia (WM)/ lymphoplasmacytic lymphoma (LPL) is an indolent mature B-cell neoplasm. In rare cases of WM/LPL, diffuse large B-cell lymphoma (DLBCL) develops as a result of histologic transformation. In this report, we present a case of DLBCL developing in a patient with WM/LPL. Combination chemotherapy for DLBCL was effective and complete remission was eventually achiev...

Journal: :Acta biochimica et biophysica Sinica 2015
Guang Yang Qianqiao Zhang Yuanyuan Kong Bingqian Xie Minjie Gao Yi Tao Hongwei Xu Fenghuang Zhan Bojie Dai Jumei Shi Xiaosong Wu

Fucoidan is one of the major sulfated polysaccharides isolated from brown seaweeds. In this study, we determined the anti-cancer activity of fucoidan on diffuse large B cell lymphoma (DLBCL) cells both in vitro and in vivo. Fucoidan inhibited the growth of DLBCL cells in a dose- and time-dependent manner, and fucoidan treatment provoked G0/G1 cell cycle arrest, which was accompanied by p21 up-r...

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