Human leukocyte antigens class II play an important role in immune response against HCV. We investigated whether HLA class II alleles influence susceptibility to HCV infection and response to interferon therapy. HLA-DRB1 and -DQB1 loci were genotyped using PCR-SSO Luminex technology. According to our regimen, 41 (66%) of patients achieved sustained virological response to combined treatment of ...

We used our database of VLT-UVES quasar spectra to build up a sample of 70 Damped Lyman-α (DLA) or strong sub-DLA systems with total neutral hydrogen column densities of log N(H ) > ∼ 20 and redshifts in the range 1.7 < z abs < 4.3. For each of the systems, we measured in an homogeneous manner the metallicities relative to Solar, [X/H] (with X = Zn, or S or Si), and the velocity widths of low-...

In an ongoing programme to identify a sample of high z DLA galaxies we have found the long sought for case of a Lyα emitter seen in the centre of a broad DLA trough. This is the predicted “textbook case” of an intervening DLA galaxy if DLA galaxies are small, but would not be expected if intervening high redshift DLA galaxies have large gaseous disks. The Lyα flux is 5.4 −0.8 × 10 ergs scm simi...

BACKGROUND The relationship between HLA-DRB1 alleles and asthma is controversial. The purpose of this study was to evaluate the relationship between HLA-DRB1 alleles and risk of asthma. MATERIAL AND METHODS We searched PubMed, Chinese National Knowledge Infrastructure (CNKI), Wan Fang (Chinese) database, and Chinese Biomedical Medical databases (CBM) to find studies on the relationship between ...

background: the human leukocyte antigen-drb1 (hla-drb1) locus is one of the most polymorphic human loci and has a crucial role in the immune system. assessing the allelic frequencies of hla-drb1 locus would be a fundamental factor in defining the origin of populations, relationships with other populations, disease association studies and the constitution of unrelated bone marrow donor registrie...

Background and Purpose Our purpose was to develop a deep learning angiography (DLA) method to generate 3D cerebral angiograms from a single contrast-enhanced acquisition. Material and Methods Under an approved IRB protocol 105 3D-DSA exams were randomly selected from an internal database. All were acquired using a clinical system (Axiom Artis zee; Siemens Healthineers) in conjunction with a sta...

To clarify the association between HLA-DRB1 alleles and chronic myelogenous leukemia (CML), the HLA-DRB1 allele frequencies in 50 Japanese patients each with b2a2 and b3a2 CML and 127 healthy Japanese individuals were examined. In the patients with b2a2 CML, the frequencies of HLA-DRB1*0405, DRB1*08032, and DRB1*1502 were low and that of HLA-DRB1*1201 was high in comparison with the healthy ind...

BACKGROUND To investigate the therapeutic effect of far infrared rays and compression bandaging in the treatment of chronic lymphedema with dermatolymphangioadenitis (DLA). METHODS Between 2005 and 2013, 106 patients with chronic lymphedema with DLA treated at the Shanghai Ninth People's Hospital were retrospectively reviewed. These patients were divided into an infrared and a bandaging group...

There are limitations in pre-clinical settings using mice as a basis for clinical development in humans. In cancer, similarities exist between humans and dogs; thus, the dog patient can be a link in the transition from laboratory research on mouse models to clinical trials in humans. Knowledge of the peptides presented on MHC molecules is fundamental for the development of highly specific T cel...