This study reviews the renal aspects of diuretic resistance occurring in treatment, mostly with loop diuretics congestive heart failure. A short discussion on different classes diuretics, including recently introduced sodium-glucose transporter 2 inhibitors, and their mechanism action nephron is provided, followed by a summary recent data discussing causes pathophysiological mechanisms resistan...

Administration of the selective adenosine A1 receptor antagonist, CVT-124, to conscious chronically instrumented rats resulted in significant increases in urine flow rate and sodium excretion without affecting potassium excretion or renal hemodynamics. Its maximum effect was twice that of hydrochlorothiazide which was associated with a significant kaliuresis. The diuretic effect of CVT-124 was ...

Separation of the urinary excretory products of the organomercurial diuretic, meralluride (Mercuhydrin) has been possible using adsorption chromatography. Practically all of the mercury is excreted in a form closely resembling the administered meralluride. Most of the excretion occurs within the first 6 hours in both cardiac patients and normal subjects. The amount of mercury excreted as degrad...

Patients with chronic renal insufficiency (CRI) or the nephrotic syndrome frequently manifest diuretic resistance. Factors limiting diuretic responsiveness in patients with CRI may include a reduced basal level of fractional Na(+) reabsorption that places an upper limit on diuretic response, and enhanced NaCl reabsorption in downstream segments, combined with a reduced delivery of diuretic to t...

Alocasia macrorrhizos (AM) belongs to the family Araceae, different parts of this plant have shown hepatoprotective, anti-oxidant and anti-inflammatory action. Though it is traditionally used as a diuretic it needs substantial experimental evidence to support this. Hence we aimed to evaluate the diuretic activity of hydroalcoholic extract of leaves of AM in wistar rats. Acute diuretic activity ...

ORAL chlorothiazide has been shown by a number of workers to be effective as an antihypertensive as well as a diuretic agent.1-'5 Parenteral mercurial diuretics likewise have been found to exert a hypotensive action in hypertensive subjects with or without complicating heart failure.12' 13, 16 Although the mode of action of these diuretic agents on the blood pressure has not been clearly determ...

Treatment of ischemic hypertensive patients with hydrochlorothiazide can precipitate cardiac arrhythmias. The present study was undertaken to evaluate the diuretic potential of green tea alone and its effects on hydrochlorothiazide in interactive groups. Rats were treated with high (500 mg/kg, p.o.) and low (100 mg/kg, p.o.) dose of green tea extract in alone and interactive groups for 30 days....