SEE PAGE 580 F luid overload and the resultant signs and symptoms, such as dyspnea, are the predominant factors precipitating a hospitalization for acute heart failure. The first-line treatment to relieve this congestion are loop diuretic agents, which are administered to more than 90% of patients hospitalized for acute heart failure (1). Heart failure guidelines recommend treatment with escala...

The whole plant, Pergularia daemia (Family: Asclepediaceae), was extracted with 50% alcohol and a fresh batch of the plant material was successively extracted with petroleum ether, ethyl acetate and n-butanol to determine its diuretic activity. The diuretic activity of the different extracts at a dose of 400 mg/Kg was assessed orally in rats with furosemide as a standard drug using Lipschitzs t...

the diuretic activity of methanol extract of oxystelma esculentum aerial parts (meoe) was studied in male wister albino rats at 5h and 24h interval. the animals were divided into 5 groups: control, urea, furosemide and 200mg/kg and 400mg/kg meoe. the extract was administered intraperitoneally (i.p) pretreated and all animals were saline meoe. the urine volume (in ml) and electrolytes excretion ...

By selectively regulating solute or fluid reabsorption, the kidneys play the major role in maintaining the volume and composition of extracellular fluid. Many diseases, including congestive heart failure, hepatic cirrhosis, and Cushing’s syndrome (glucocorticoid excess), are associated with or cause significant alterations in extracellular fluid balance. Diuretics inhibit renal sodium transport...

Aims To study loop diuretic response and effect of omission in ambulatory heart failure (HF) patients on chronic low-dose diuretics. Methods results Urine collections were performed two consecutive days 40 HF with 40–80 mg furosemide (day 1 diuretic; day 2 without diuretic). Three phases collected each day: (i) first 6 h; (ii) rest the day; (iii) night. On intake, total natriuresis was 125.9 (8...

the present study was designed to investigate the diuretic activity of Musa sapientum l. (familyMusaceae) flowers. The dried powder of the flower was subjected to Soxhlet extraction with alcohol and this extract was used for diuretic activity in Wistar albino rats using lipschitz method. the diuretic activity was assessed in terms of urine output and, concentration of Sodium, Potassium and Chlo...

Purpose: To evaluate the diuretic effect of the aqueous methanol extract of Mentha viridis Linn (Labiatae) in Albino rats. Methods: The aqueous-methanol extract of Mentha viridis was administered to experimental rats at doses of 30, 50 and 100 mg/kg, (i.p.) Furosemide 10 mg/kg (i.p.) and normal saline were used as reference drug and control, respectively. Diuretic effect was examined immediatel...

To study the diuretic effects of cleistanthin A and cleistanthin B, phytoconstituents were isolated from the leaves of Cleistanthus collinus in Wistar rats. The in vivo diuretic effects of cleistanthins A and B were determined according to the Lipschitz test. Prior to the experiment, the animals were fasted for 5 h and placed individually in metabolic cages. Cleistanthins A and B (12.5, 25, and...

  The common use of maternal ultrasonography has increased the apparent incidence of neonatal hydronephrosis. Many of these cases are found to have partial obstruction at the ureteropelvic junction (UPJ). These patients are safely managed in our institution with careful observation and only occasionally require surgical intervention. The authors present two contrastin...

AIMS We studied the characteristics and clinical outcome related to diuretic response and the effects of serelaxin in patients hospitalized for acute heart failure (AHF). METHODS AND RESULTS RELAX-AHF was a double-blind, placebo-controlled trial, enrolling 1161 patients admitted to hospital for AHF who were randomized to 48 h i.v infusions of placebo or serelaxin (30 µg/kg per day) within 16 ...