Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that is widely used for the treatment of mild-to-moderate pain. Mefenamic acid belongs to the Biopharmaceutical Classification System (BCS) class II drug which has lower water solubility but high permeability. There are two different compendial methods available for dissolution tests of mefenamic acid solid dosage forms, i.e. meth...

A new specific, accurate, precise, and reproducible selective online dissolution method for rosiglitazone maleate is developed and validated for the dissolution of rosiglitazone maleate in pharmaceutical formulations. The rationale of the method is based on the direct measurement of the absorbance of the analyte in the buffer medium at 242 nm using buffer as blank. Dissolution is achieved on a ...

The intended purpose of this work is to develop and validate a dissolution test for betamethasone acetate and betamethasone sodium phosphate injectable suspension using a reverse-phase liquid chromatographic method. After testing sink conditions, dissolution medium and stability of the drug, the best conditions were: flow through cell of diameter 22.6 mm, 2.0 ml per minutes flow rate for 120 mi...

The evaluation of chemical dissolution phenomena of the glasses in general is important because it is related to the bioactivity. This paper aims a comparative study of the bioglass dissolution between in vitro bioactivity test in SBF (Simulated Body Fluid) solution and the chemical durability test, in glasses on SiO2-Na2O-CaO with 6wt% de P2O5 system. The glasses were obtained by melting at 15...

To prepare powdered drugs that do not have a bitter taste, a film coating covering the surfaces of the core particles is required. The dissolution rate of ibuprofen from the coated particles changes according to the physical properties of the core particles. In this study, the effects of the physical properties of granules prepared by using several scales of agitation fluidized beds on the drug...

Dissolution tests that can predict the in vivo performance of drug products are usually called biorelevant dissolution tests. Biorelevant dissolution testing can be used to guide formulation development, to identify food effects on the dissolution and bioavailability of orally administered drugs, and to identify solubility limitations and stability issues. To develop a biorelevant dissolution t...

Cross-linking is a common problem in the dissolution of gelatin capsules. Cross-linking is characterized by a bridge across the peptide backbone of the gelatin molecule which creates water insoluble membranes or pellicles during dissolution testing. The chemical covalent bonding between gelatin chains is typically triggered by catalytic amounts of aldehyde and/or from exposure to high temperatu...

Introduction Used in the private or public USP Performance test, dissolution testing plays an important role in both product development and quality assurance for nonsolution oral dosage forms. The dissolution procedure itself,as described in USP General Chapter Dissolution <711>, is sensitive and specific but requires special care in execution. Results of a recent USP collaborative study of ne...

List of contents  DEFINITION OF DISSOLUTION PROFILE  IMPORTANCE OF DISSOLUTION PROFILE  METHODS TO COMPARE DISSOLUTION PROFILE (A) GRAPHICAL METHODS (B) STATISTICAL ANALYSIS t-TEST ANOVA (C) MODEL DEPENDENT METHODS : (a)Introduction (b)Zero order A.P.I. release (c)First order A.P.I. release (d)Hixson Crowell cube root law (e)Takeru Higuchi model (f)Weibull model (g)Korsemeyar and peppas mode...

Similarity in Dissolution behavior of drugs has long been sought from the percpective of both bioavailability and quality control considrations. The objective of this study was to apply several profile comparison to dissolution data of three different batches of Indomethacin (SR) which two of them were German products as the refernce batches. Dissolution was performed using the United States Ph...