PURPOSE This study describes the development and validation of dissolution tests for fexofenadine hydrochloride capsules and coated tablets using an HPLC method. METHOD The appropriate conditions were determinate after testing sink conditions, dissolution medium, and agitation intensity. The apparatus, paddle and basket, were applied to tablets and capsules, respectively. Fexofenadine hydroch...

ibuprofen solid dispersions were prepared by the solvent and fusion-solvent methods using polyethylene glycol (peg), polyvinylpyrrolidone (pvp), eudragit rs po, eudragit rl po and hydroxypropylmethylcellulose (hpmc) as carriers to improve physicochemical characteristics of ibuprofen. the prepared solid dispersions were evaluated for the flowability, solubility characteristics and dissolution be...

Biorelevant in vitro dissolution is a useful technique for qualitative forecasting of the in vivo behavior of a formulation. A biorelevant dissolution medium for simvastatin was developed with a lower concentration of surfactant (0.1% sodium lauryl sulfate, SLS) in the medium as compared with the 0.5% SLS concentration stated in the USP monograph. The slower dissolution rate of simvastatin tabl...

       The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a ...

OBJECTIVE To compare the dissolution properties of Ginseng micropowder and common powder in vitro and investigate the effect of micronization on dissolution of Ginseng. METHODS Five ginsenosides including Rg1, Re, Rf, Rb1, and Rb2 were determined by high performance liquid chromatography, and the dissolution curves of Ginseng micropowder and common powder were drawn. RESULTS The dissolution...

The establishment of biorelevant and discriminating dissolution procedure for drug products with limited water solubility is a useful technique for qualitative forecasting of the in vivo behavior of formulations. It also characterizes the drug product performance in pharmaceutical development. Lornoxicam, a BCS class-II drug is a nonsteroidal antiinflammatory drug of the oxicam class, has no of...

the effects of crystallization of indomethacin as a poorly water-soluble drug in aqueous surfactant solutions (using the basket method), on the drug dissolution behavior was investigated.a significant enhancement of drug dissolution was observed for for the dissolution rates of crystals treated with hydrophilic surfactants, tween 80 and sodium lauryl sulfate (sls). however, asing arlacel 60 as ...

piroxicam (px), an anti-inflammatory drug, exhibits poor water solubility, dissolution and flow properties. thus, the aim of the present study was to improve the solubility and dissolution rate of px by freeze drying technique using dimethylformamide (dmf), chloroform and water as co-solvent system. the prepared crystals containing px were evaluated for dmf and chloroform solvent residual by ga...

the formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a hydroph...