Most of the SOD mimics thus far developed belong to the classes of Mn-(MnPs) and Fe porphyrins(FePs), Mn(III) salens, Mn(II) cyclic polyamines and metal salts. Due to their remarkable stability we have predominantly explored Mn porphyrins, aiming initially at mimicking kinetics and thermodynamics of the catalysis of O2(-) dismutation by SOD enzymes. Several MnPs are of potency similar to SOD en...

Reactive oxygen/nitrogen species suppress myocardial oxygen consumption. In this study, we determined that endogenous hydrogen peroxide through dismutation of superoxide enhances postischemic myocardial blood perfusion and oxygen consumption. Electron paramagnetic resonance oximetry was applied to monitor in vivo tissue Po2 in mouse heart subjected to regional ischemia reperfusion. Heart rate, ...

The concept of weak algebraic hyperstructures or Hv-structures constitutes a generalization of the well-known algebraic hyperstructures (semihypergroup, hypergroup and so on). The overall aim of this paper is to present an introduction to some of the results, methods and ideas about chemical examples of weak algebraic hyperstructures. In this paper after an introduction of basic definitions and...

A complete chemical balance which demonstrates the occurrence of Reaction 3 has now been obtained. There is no reaction in the absence of either TPN, .Zwischenferment, or “malic” enzyme. The rate of reaction is proportional to the concentration of “malic” enzyme and to the CO* tension. It is also possible to couple the isocitric dehydrogenase-oxalosuccinic carboxylase system (2) with “malic” en...

Terminal transferase (TdT), when incubated with a purified(32)P-5"-end-labeled oligonucleotide of defined length in the presence of Co(2+), Mn(2+)or Mg(2+)and 2-mercaptoethanol in cacodylate or HEPES buffer, pH 7.2, exhibits the ability to remove a 3"-nucleotide from one oligonucleotide and add it to the 3"-end of another. When analyzed by urea-PAGE, this activity is observed as a disproportion...

Eleven flavoproteins from the old yellow enzyme family were found to catalyze the disproportionation ("dismutation") of conjugated enones. Incomplete conversions, which were attributed to enzyme inhibition by the co-product phenol could be circumvented via in situ co-product removal by scavenging the phenol using the polymeric adsorbent MP-carbonate. The optimized system allowed to reduce an al...

Reaction 1 requires DPN and manganous ions. It is specific for Imalic acid; d-malic acid is inactive. TPN cannot replace DPN. Reaction 2 requires the presence of manganous ions. The evidence presented below supports the view that Reaction 1 is a DPN-linked dismutation between Z-malate and pyruvate, resulting from the interaction of lactic dehydrogenase with a DPN-specific “malic” enzyme as show...

Abstract. Photo-chemically induced dynamic nuclear polarization (photo-CIDNP) was used to observe the light-induced disproportionation reaction of 6,7,8-trimethyllumazine starting out from its triplet state generate a pair radicals comprising one-electron reduced and oxidized species. Our evidence is based on measurement two marker proton hyperfine couplings, Aiso(H(6α)) Aiso(H(8α)), which we c...