نتایج جستجو برای: disheveled proteins
تعداد نتایج: 555711 فیلتر نتایج به سال:
The Rockefeller University Press $30.00 J. Cell Biol. Vol. 192 No. 1 171–188 www.jcb.org/cgi/doi/10.1083/jcb.201008060 JCB 171 Correspondence to Marlene Rabinovitch: [email protected] Abbreviations used in this paper: ANOVA, analysis of variance; AoSMC, aortic SMC; Apo, apolipoprotein; ARD, ankyrin repeat domain; C, -catenin; BMP, bone morphogenetic protein; BMPRII, BMP receptor II; Co-IP...
Someone once observed that every decade the real estate industry invents a new vehicle for wealth transfer between the inventors and their investors. During my career we have seen this drama play out many times. New wrinkles in capital markets often lead to disheveled portfolios. In the mid 1970s, major banks seized on the mortgage real estate investment trust (REIT) as a vehicle to make loans ...
Cilia defects have been implicated in a variety of human diseases and genetic disorders, but how cilia motility contributes to these phenotypes is still unknown. To further our understanding of how cilia function in development, we have cloned and characterized two alleles of seahorse, a zebrafish mutation that results in pronephric cysts. seahorse encodes Lrrc6l, a leucine-rich repeat-containi...
Cyto-nuclear shuttling of β-catenin is at the epicenter of the canonical Wnt pathway and mutations in genes that result in excessive nuclear accumulation of β-catenin are the driving force behind the initiation of many cancers. Recently, Naked Cuticle homolog 1 (Nkd1) has been identified as a Wnt-induced intracellular negative regulator of canonical Wnt signaling. The current model suggests tha...
Cilia are microtubule-based projections that function in the movement of extracellular fluid. This requires cilia to be: (1) motile and driven by dynein complexes and (2) correctly polarized on the surface of cells, which requires planar cell polarity (PCP). Few factors that regulate both processes have been discovered. We reveal that C21orf59/Kurly (Kur), a cytoplasmic protein with some enrich...
The National Southern Cross Road Route well known as Jalan Jalur Lintas Selatan (JJLS) in Indonesia. segment which crosses Bantul Regency has 16.65 km long. development of JJLS will have various kinds impacts on the community around road infrastructure. This study wants to know how impact that saw from spatial dynamics land-use change. area is located Poncosari, Gadingsari, Srigading, Tirtoharg...
statement of problem: periodontal disease (pd) has been linked to adverse cardiovascular events by unknown mechanisms. c-reactive protein (crp) is a prognostic marker for cardiovascular disease, with reported elevated serum levels during pd. purpose: the aim of the present study was to evaluate the association between pd and higher crp levels in the serum of acute myocardial infarction (ami) pa...
We describe a family with a novel, inherited AXIN2 mutation (c.1989G>A) segregating in an autosomal dominant pattern with oligodontia and variable other findings including colonic polyposis, gastric polyps, a mild ectodermal dysplasia phenotype with sparse hair and eyebrows, and early onset colorectal and breast cancers. This novel mutation predicts p.Trp663X, which is a truncated protein that ...
The Wnt signaling pathway is frequently deregulated in cancer due to mutations in genes encoding APC, beta-catenin, and axin. To identify small-molecule inhibitors of Wnt signaling as potential therapeutics, a diverse chemical library was screened using a transcription factor reporter cell line in which the activity of the pathway was induced at the level of Disheveled protein. A series of deco...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید