Two disease severity scoring systems, the Mainz Severity Score Index (MSSI) and Fabry Disease Severity Scoring System (DS3), have been validated for quantifying the disease burden of Fabry disease. We aimed to develop a dynamic mathematical model [the FASTEX (FAbry STabilization indEX)] to assess the clinical stability. A multidisciplinary panel of experts in Fabry disease first defined a novel...

background: investigators frequently encounter continuous outcomes with plenty of values clumped at zero called semi-continuous outcomes. the gensini score, one of the most widely used scoring systems for expressing coronary angiographic results, is of this type. the aim of this study was to apply two statistical approaches based on the categorization and original scale of the gensini score to ...

BACKGROUND Multidetector CT coronary angiography (MDCTCA) is capable of detecting coronary artery disease (CAD) with a high diagnostic accuracy. In particular, this technique is credited with having a negative predictive value close to 100%. However, data about the prognostic value of MDCTCA are currently lacking. We sought to determine the prognostic value of MDCTCA in patients with suspected ...

multiple sclerosis (ms) is an autoimmune inflammatory, demyelinating disease of human central nervous system. experimental autoimmune encephalomyelitis (eae) is the commonly used animal model of ms. calorie restriction has been found to reduce inflammation and autoimmune responses and promote neuroprotection. in this study we evaluated the effects of intermittent feeding protocol of the calorie...

We welcome the interest shown by colleagues in Rome about the Ulcerative Colitis Endoscopic Index of Severity [UCEIS]1,2 and their suggestion that it might be enhanced by segmental scoring at full colonoscopy. When the score was being developed,3 the international working group felt that a major goal was for the score to be simple, not to replicate the relative complexity of endoscopic scoring ...

Introduction A Disease Severity Scoring System (DS3) measures disease burden in patients. It consists of critical health domains, each described by relevant clinical assessment(s) quantified via reliable, valid and feasible methods. DS3s are particularly useful in rare, heterogeneous diseases in which evaluating severity and prognosis is difficult. Properly configured, a DS3 provides interand i...