Testosterone (250 microM), 7-ethoxycoumarin (25 microM), and 1-chloro-2,4-dinitrobenzene (CDNB, 50 microM) were used as substrates to compare phase I and II metabolism in rat precision-cut liver slices and rat hepatocytes. Overall clearance to metabolites was significantly greater in hepatocytes for testosterone (1.9- to 16.9-fold), 7-ethoxycoumarin (O-deethylation, 14.8-fold; glucuronidation, ...

INTRODUCTION Nurses' Caring behaviors might be affected by many variables. The aim of this study was to develop and test a valid and reliable questionnaire to specify these determinants. METHODS Both qualitative and quantitative methods were applied to develop the questionnaire. The development process of the instrument was conducted in three phases. The first phase consisted of four steps: i...

The study of leprosy in children has indicated an incidence of 10% amongst leprosy patients attending the clinic. The duration of the disease was usually less than 2 years. The expression of leprosy in this group was either a macule and/or a plaque. Classification was, therefore, different and conforms to indeterminate (I), borderline tuberculoid (BT) and borderline (BB) leprosy. Only occasiona...

The susceptibility of patients with Hodgkin's disease to mycotic and viral infections has long directed attention to an immunological defect in that condition (1). The early finding of tuberculin negativity in these patients (2, 3), even in the presence of active tuberculous infection, has been confirmed repeatedly. Subsequent investigations have indicated that this cutaneous anergy extends to ...