A novel stability-indicating reverse phase high performance liquid chromatography method was developed and validated for the simultaneous determination of Celecoxib (CEL) and Diacerein (DIN) and its impurities in capsule dosage form. The method was developed using L1 column with gradient using the mobile phase consist of Solution A (pH = 2.3 buffer) and Solution B (methanol and acetonitrile; 50...

In nitrogen (N)-limited systems, the potential to sequester carbon depends on the balance between N inputs and losses as well as on how efficiently N is used, yet little is known about responses of these processes to changes in plant species richness, atmospheric CO2 concentration ([CO2]), and N deposition. We examined how plant species richness (1 or 16 species), elevated [CO2] (ambient or 560...

tinere talente recrutate de profesorul Thoma Ionescu, a cărui intuiţie în alegerea colaboratorilor, viitorilor profesori de chirurgie, şefi de şcoală la rândul lor, nu a dat niciodată greş. Născut la 14 mai 1870 în oraşul Bârlad, acest fiu strălucit al pământului Moldovei, a reuşit prin calităţile sale înnăscute, dar mai ales printr-o muncă ordonată şi neobosită, să făurească o operă nepieritoa...

In this study biogeochemical export in a set of catchments that vary from 6ha to almost 1500ha is investigated. Studying catchments across this large range of scales enables us to investigate the scale dependence and fundamental processes controlling catchment biogeochemical export that would not have been possible with a more limited data set. The Devil Canyon catchment, in the San Bernardino ...

Water originating from coal-bed natural gas (CBNG) production wells typically contains ammonium and is often disposed via discharge to ephemeral channels. A study conducted in the Powder River Basin, Wyoming, documented downstream changes in CBNG water composition, emphasizing nitrogen-cycling processes and the fate of ammonium. Dissolved ammonium concentrations from 19 CBNG discharge points ra...

In this paper we have analyzed the phytoestrogen content of Glycyrrhiza glabra roots harvested from four different locations in Syria. The presence of eight phytoestrogen compounds was simultaneously assessed through a LC-MS method, before and after hydrolysis. All tested extracts contain daidzein, daidzin, genistein, formononetin, ononin and coumestrol. Rezumat În această lucrare am analizat c...

We analyze possible future trends in dissolved inorganic nitrogen (DIN) export by world rivers and associated emissions of nitrous oxide (N2O). Our scenarios either assume that current trends continue or that nitrogen (N) inputs to aquatic systems are reduced as a result of changes in agriculture practices and fuel combustion technologies. The results indicate that moderate changes in the human...

Objective: To outline the major methodological issues appropriate to the use of the population impact number (PIN) and the disease impact number (DIN) in health policy decision making. Design: Review of literature and calculation of PIN and DIN statistics in different settings. Setting: Previously proposed extensions to the number needed to treat (NNT): the DIN and the PIN, which give a populat...

We investigated the properties of an artificial chimeric peptide that contains an Arg-Gly-Asp (RGD)tripeptide, the versatile cell recognition signal of extracellular matrix protein components, coupled to a carboxyl-terminal fragment of the highly specific a-thrombin hibitor, hirudin (residues 53-64): WG-SANGDFEEIPEEYL (RGD-hir~din'~-'~). Hir ~ d i n ~ ~ ' ~ and RGD-hir~din'~-'~ inhibited th...