The etiology of Parkinson disease (PD) is unclear but may involve environmental toxins such as pesticides leading to dysfunction of the ubiquitin proteasome system (UPS). Here, we measured the relative toxicity of ziram (a UPS inhibitor) and analogs to dopaminergic neurons and examined the mechanism of cell death. UPS (26 S) activity was measured in cell lines after exposure to ziram and relate...

0020-1693/$ see front matter 2011 Elsevier B.V. A doi:10.1016/j.ica.2011.07.031 ⇑ Corresponding author. Tel.: +39 49 8275172; fax: E-mail address: [email protected] (D. Mo The polymeric [PdCl(dithiocarbamate)]n complexes, in which the ligand ion is dimethyldithiocarbamate (DMDT), pyrrolidine dithiocarbamate (PyDT, (CH2)4NCS2 ) and sarcosine ethyl ester dithiocarbamate (ESDT, EtO2CCH2N(CH...

For decades chromated copper arsenate (CCA) was the primary preservative for treated wood used in residential construction. However, recent label changes submitted by CCA registrants will withdraw CCA from most residential applications. This action has increased interest in arsenic-free preservative systems that have been standardized by the American Wood Preservers’ Association. These include ...

Features of pesticide synergism and acetylcholinesterase (AChE) inhibition (in vitro) were studied using a selected range of organotin compounds against the early 4th instar larvae of a highly resistant strain of the diamondback moth (DBM), Plutella xylostella, a major universal pest of cruciferous vegetables.Fourteen triorganotin compounds were evaluated for their ability to enhance the toxici...

Ferrous-nitrosyl {FeNO}(7) complexes, whether S = 1/2 or 3/2, generally exhibit bent FeNO angles of around 140-145 degrees . There are, however, a handful of exceptions, which are characterized by linear or quasi-linear FeNO units. Presented herein is a relatively comprehensive DFT-based MO analysis of these unusual {FeNO}(7) complexes. DFT-derived FeNO bending potentials indicate that the unus...

N,N-Dimethyldithiocarbamate (DMDTC) is a typical precursor of N-nitrosodimethylamine (NDMA). Based on separate hydrolysis, sorption and biodegradation studies of DMDTC, a laboratory-scale anaerobic-anoxic-oxic (AAO) system was established to investigate the removal mechanism of DMDTC in this nutrient removal biological treatment system. DMDTC hydrolyzed easily in water solution under either aci...

Menkes disease is a fatal neurodegenerative disorder in infants caused by mutations in the gene ATP7A which encodes a copper (Cu) transporter. Defects in ATP7A lead to accumulated copper in the small intestine and kidneys and to copper deficiencies in the brain and the liver. The copper level in the kidney in postnatal copper-treated Menkes patients may reach toxic levels. The mouse model, mosa...