Secreted by the adipose tissue, adiponectin is an adipokine with unique anti-diabetic, anti-obesity and antiatherosclerosis properties. Adiponectin has been proposed as a drug target for treating obesity-related diseases and many existing drugs have been found to regulate circulating adiponectin levels in humans. The initial goal of this study was to characterize the binding of potential ligand...

The structure of the title compound, [CrCl2(C2H6OS)4]Cl·C2H6OS, consists of a Cr(III) ion coordinated by four O atoms of dimethyl sulfoxide (DMSO) ligands and two chloride ions in cis positions, forming a distorted CrCl2O4 octa-hedron. An isolated Cl(-) counter-anion and a positionally disordered DMSO mol-ecule [occupancy ratio 0.654 (4):0.346 (4)] are also present. In the structure, the comple...

6.2 DIMETHYL SULFOXIDE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 6.2.1 Action of DMSO on SW620 cells in culture . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 6.2.1.1 Growth rate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 6.2.1.2 Morphology . . . . . . . . . . . . . . . . . . . ...

β-Haloalkoxysulfonium ions generated by the reaction of electrogenerated Br(+) and I(+) ions stabilized by dimethyl sulfoxide (DMSO) reacted with sodium hydroxide and sodium methoxide to give the corresponding halohydrins and epoxides, respectively, whereas the treatment with triethylamine gave α-halocarbonyl compounds.

A palladium-catalyzed annulation of ortho-vinylanilines with dimethyl sulfoxide was developed to access 4-aryl quinolines in moderate to good yields. Activated by 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct (DABSO), DMSO served as a "[double bond, length as m-dash]CH-" fragment in this transformation. It represents a facile pathway leading to 4-aryl quinolines.

The studies demonstrated that the use of dimethyl sulfoxide (DMSO) as a vehicle for dimethylbenzanthracene in the produc tion of experimental tumors in the hamster cheek pouch, sig nificantly reduced the latent period for tumor production when compared to the usual mineral oil vehicle. No systemic or local changes could be attributed to the DMSO itself, and the mor phology of induced tumors was...

Ninety-six strains of Candida, including 29 resistant and 67 susceptible isolates with mutations in the FKS1 and FKS2 genes were tested by the European Committee on Antibiotic Susceptibility Testing EDef 7.1 and 7.2 methodologies to determine the impact on the MIC when water was replaced with dimethyl sulfoxide (DMSO) as the solvent for caspofungin and micafungin. The MICs were significantly lo...

Dimethyl sulfoxide (DMSO) added to agar overlays during plaque assays of simian virus 40 (SV40) in CV1 monkey cells increases the plaque size and number and enables plaques to be read several days earlier than usual. DMSO appears to act during development of plaques, perhaps by causing cell lysis at smaller burst sizes in the presence of near-lethal DMSO concentrations. It does not act synergis...

Complexes [MII(2-pytz)Cl2] (M(II) = Pt, Pd; 2-pytz 2-(tetrazol-1-yl)pyridine) were synthesised via direct interaction of the corresponding metal chlorides (K2PtCl4 or PdCl2) with under ambient conditions. RuCl3 does not react reflux in protic media, while N, N-dimethylformamide presence LiCl, decomposition tetrazole cycle occurred leading to formation Ru(III)-coordinated N-dimethyl-N ′-(pyridin...

Introduction Methylsulfonylmethane (MSM), also known as dimethyl sulfone (DMSO 2 ) and methyl sulfone, is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains, and animals including humans. A white, odorless, slightly bitter-tasting crystalline substance containing 34-percent elemental sulfur, MSM is a normal oxidative metabolite product of dime...