1: procedure CC-CMA-ES(dim, subN um, lambda, ub, lb, maxF Es) 2: pop(1 : 200, 1 : dim) ← random population 3: (best, best val) ← evaluate(pop) 4: f es ← 200 5: C ← dim × dim unit matrix 6: xw ← dim × 1 random vector 7: σ ← (ub − lb) ÷ 2 8: historyW indow ← 5 9: perf ormanceRecord ← ones(3, historyW indow) 10: while f es < maxF Es do 11: (subInf o, decomposerID) ← adaptiveDecompose(dim, subN um,...

The DIM series of preneoplasms, developed from the BALB/c mam mary cell line COMMA-D, and DIM-derived tumors were examined for evidence of mouse mammary tumor virus (MM I V) involvement in the tumorigenic process. DIM tissues were shown to be free of exogenous MMTV inasmuch as Southern blot analysis of DNAs extracted from DIM preneoplasms and tumors showed the lack of a /VI-generated 4.2kilobas...

Studies in humans have shown that 3,3'-diindolylmethane (DIM), which is found in cruciferous vegetables, such as cabbage and broccoli, is effective in the attenuation of gastrointestinal cancers. This review presents the latest findings on the use, targets, and modes of action of DIM for the treatment of human gastrointestinal cancers. DIM acts upon several cellular and molecular processes in g...

Lecture Notes taken by Nilufer Koldan In this lecture I will describe one of the most significant achievements of the second half of the XX century – the Atiyah-Singer index theorem. I will also discuss some more recent developments in the area as well as some open problems. 1. The definition of the index 1.1. The finite-dimensional case. Let A : V 1 → V 2 be a linear map between finite dimensi...

In this paper, new definitions of a fuzzy basis and a fuzzy dimension for a fuzzy vector space are presented. A fuzzy basis for a fuzzy vector space (E, μ) is a fuzzy set β on E. The cardinality of a fuzzy basis β is called the fuzzy dimension of (E, μ). The fuzzy dimension of a finite dimensional fuzzy vector space is a fuzzy natural number. For a fuzzy vector space, any two fuzzy bases have t...

We introduce the concept of the ghost dimension gh. dim. R of a ring R. This is the longest nontrivial chain of maps in the derived category emanating from a perfect complex such that each map is zero on homology. We show that gh. dim. R ≤ w. dim. R, with equality if R is coherent or w. dim. R = 1.

BACKGROUND The objective of this study was to demonstrate the anti-skin cancer and chemopreventive potential of 1,1-bis(3'-indolyl)-1-(p-chlorophenyl methane) (DIM-D) using an in vitro model. METHODS In vitro cell cytotoxicity and viability assays were carried out in A431 human epidermoid carcinoma cell line and normal human epidermal keratinocytes (NHEK) respectively by crystal violet staini...

ABSTRACT The disc instability mechanism (DIM) is widely accepted to account for the transient behaviour of dwarf novae (DNe), which experience short outbursts separated by long quiescence. duty cycle (the ratio between outburst duration and recurrence time) determines amount accreted mass white (WDs) during outbursts, thus playing an important role in long-term binary evolution. Employing code ...

Functionally distinct chromatin domains are delineated by distinct posttranslational modifications of histones, and in some organisms by differences in DNA methylation. Proper establishment and maintenance of chromatin domains is critical but not well understood. We previously demonstrated that heterochromatin in the filamentous fungus Neurospora crassa is marked by cytosine methylation directe...