Diffusion tensor imaging has been increasingly used for studying white matter pathology in rodent models of neurological diseases. Here, applications of diffusion tensor imaging in detecting major and subtle white matter pathology in the mouse CNS are reviewed, followed by several technical details that may be helpful in designing studies that involve diffusion tensor imaging of rodent brain an...

We propose a class of estimation techniques for scalar-on-function regression where both outcomes and functional predictors may be observed at multiple visits. Our methods are motivated by a longitudinal brain diffusion tensor imaging tractography study. One of the study's primary goals is to evaluate the contemporaneous association between human function and brain imaging over time. The comple...

3 Telsa MR scanners are now becoming more widely available and 3 Telsa is likely to become the filed strength of choice for clinical imaging of the brain. The neonatal brain can be safely and successfully imaged at 3 Telsa. The improved signal to noise afforded by a higher field strength may be used to improve image quality or shorten acquisition times. This may be exploited for conventional T1...

We evaluate a recent statistical tractography technique for analyzing the diffusion tensor imaging data using new criteria and the template from the Tractometer. This novel method simultaneously achieves excellent percentages on 3 out of 7 criteria. Compared to deterministic tractography methods, it is superior to all of them. Compared to probabilistic tractography methods, it has similar resul...

Second-order tensors may be described in terms of shape and orientation. Shape is quantified by tensor invariants, which are fixed with respect to coordinate system changes. This chapter describes an anatomically-motivated method of detecting edges in diffusion tensor fields based on the gradients of invariants. Three particular invariants (the mean, variance, and skewness of the tensor eigenva...

This paper describes an approach for making use of the components of the experimentally determined rotational diffusion tensor derived from NMR relaxation measurements in macromolecular structure determination. The parameters of the rotational diffusion tensor describe the shape and size of the macromolecule or macromolecular complex, and are therefore complementary to traditional NMR restraint...

In this paper we present a novel Bayesian approach for fractional segmentation of white matter tracts and simultaneous estimation of a multi-tensor diffusion model. Our model consists of several white matter tracts, each with a corresponding weight and tensor compartment in each voxel. By incorporating a prior that assumes the tensor fields inside each tract are spatially correlated, we are abl...