Impairment of the ubiquitin-proteasome system (UPS) has long been considered an attractive hypothesis to explain the selective dysfunction and death of neurons in polyglutamine disorders such as Huntington's disease (HD). The fact that inclusion bodies in HD mouse models and patient brains are rich in ubiquitin and proteasome components suggests that the UPS may be hindered directly or indirect...

My G4G8 exchange item is a screw-together cube made of two identically shaped nylon parts, one dyed red and one dyed yellow. It can be seen as a cube sliced by the propeller of an airplane flying through it. Formally, it is cube which has been split along a helicoid surface whose axis is aligned with a two-fold axis of the cube, i.e. passing from one edge midpoint to the opposite edge midpoint....

We compute the statistical entropy of the three charge (D1-D5-p) five dimensional black hole to sub-leading order in a large charge expansion. We find an agreement with the macroscopic calculation of the Wald entropy in R corrected supergravity theory. The two calculations have a overlapping regime of validity which is not the Cardy regime in the microscopic conformal field theory. We use this ...

Background and Aim: The proportion of smile is a useful tool for creating geometric smiles which are a critical aspect in esthetic dentistry. The aim of this study was to determine the effect of lip line position on acceptable Recurring Esthetic Dental (RED) proportion among lay people. Materials and Methods: A photograph of pose smile of a young female was taken. The position of the lip was c...

Background. The double haul is a unique feature of single-handed fly casting and is used in both fly fishing and fly casting competition. The movement behaviour during the double haul has not been investigated in previous research. Objectives. Describe the coordination of the rod and line hauling movements during distance fly casting. Methods. Elite fly casters performed distance castin...

This study was designed to analyze upper extremity and core muscle activation performing push-ups under different stability conditions and body positions. Trained university male students (n= 29) performed 3 push-ups each under stable conditions and using suspension device (AirFit Trainer ProTM) with their hands at 2 different heights (i.e., 10 and 65 cm). Push-up speed was controlled using a m...

In the USA and the UK, many thousands of police suspects are identified by eyewitnesses every year. Unfortunately, many of those suspects are innocent, which becomes evident when they are exonerated by DNA testing, often after having been imprisoned for years. It is, therefore, imperative to use identification procedures that best enable eyewitnesses to discriminate innocent from guilty suspect...