99mTc-Labeled annexin V has been used for the imaging of tumor apoptosis induced by chemotherapy. However, owing to the short half-life of annexin V, multiple injections of the radiotracer are necessary to capture the peak apoptotic activity. In this study, we evaluated the imaging properties of an 111Inlabeled, long-circulating annexin V. Methods: Both polyethylene glycol (PEG) and the metal c...

Chelation of the rare-earth element gadolinium (Gd) with diethylenetriaminepentaacetic acid (DTPA) results in a strongly paramagnetic, stable complex that is well tolerated in animals. The strongly paramagnetic gadolinium complex reduces hydrogen-proton relaxation times even in low concentrations (less than 0.01 mmol/L). The pharmacokinetic behavior of intravenously delivered Gd-DTPA is similar...

BACKGROUND Annexin A5 (anxA5) has been found useful for molecular imaging of apoptosis and other biological processes. METHODS Here, we report an optimised two-step synthesis of annexin A5-diethylene triamine pentaacetic acid (DTPA) (anxA5-DTPA) for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging with a single purification step. The use of a r...

In this study, BevMab was conjugated with the bifunctional chelating agent [diethylenetriamine pentaacetic acid (DTPA)] and the product (BevMab-DTPA) was labeled with Tc using stannous chloride reducing method. The quality control studies of radiolabeled compound (Tc-BevMab-DTPA) were done with Thin Layer Radio Chromatography (TLRC) and High Performance Liquid Radio Chromatography (HPLRC) metho...

Cancer detection in early stage using a powerful and noninvasive tool is of high global interest. In this experiment, a small-molecular-weight glucose based derivative of Gd3+-1-(4-isothiocyanatobenzyl) diethylene tri amine penta acetic acid (Gd3+-p-SCN-Bn‐DTPA‐DG) as a novel potential MR imaging contrast agents was synthesized. Gd3+-p-SCN-Bn‐DTPA‐DG was synthesized with reacting of Glucosamine...

Biocompatible gold nanoparticles (AuNPs) are particularly interesting for photo-thermal therapy (PTT) of cancer treatment because their ability to convert light into heating efficiently. Nevertheless, the random accumulation AuNPs in tissues, mainly determined by retention time bloodstream, is one main limiting factors use PTT applications. For this reason, efficient targeting and monitoring se...

INTRODUCTION L,L-ethylenedicysteine (EC) is a new carrier of technetium Tc 99m (99mTc) with a lower affinity to plasma albumin in comparison with diethylenetriamine pentaacetic acid (DTPA). We compared 99mTc-EC scan with 99mTc-DTPA scan in diuretic renography for patients with obstructive uropathy. MATERIALS AND METHODS Thirty-three patients with upper urinary tract obstruction were randomly ...

BACKGROUND Airway liquid hyper-absorption is a key pathophysiological link between the genetic mutations of cystic fibrosis (CF) and the development of lung disease. Here we consider whether the clearance of radiolabeled diethylene triamine pentaacetic acid (DTPA) might be used to detect changes in airway liquid absorption. METHODS Tc99m-DTPA was added to the apical (luminal) surface of prima...

7-Amino-4-trifluoromethyl-2-(1H)-quinolinone (cs124-CF3), has been synthesized and found to be an effective antenna molecule (or sensitizer) for europium, but not terbium, luminescence. Specifically, cs124-CF3 has been covalently attached to the chelates diethylenetriaminepentaacetic acid (DTPA) and triethylenepentamine-hexanoic acid (TTHA). When bound to europium, excitation in the absorption ...

Abstract models have been developed to describe dissolution of Pu/Am/Cm after internal contamination by inhalation or wound, chelation of actinides by diethylene triamine penta acetic acid (DTPA) in different retention compartments and excretion of actinide-DTPA complexes. After coupling these models with those currently used for dose calculation, the modelling approach was assessed by fitting ...