In this paper, the heat transfer to the fluid, passing through the double forward facing step (FFS) channel with square obstacle is enhanced by Taguchi’s S/N ratio analysis. Flow through the forward facing step channel has a wide range of applications in thermal systems due to its flow separation and subsequent reattachment, which in turn enhances the heat transfer. Flow separation and reattach...

Transcript elongation by bacterial RNA polymerase (RNAP) is thought to be regulated at pause sites by open versus closed positions of the RNAP clamp domain, pause-suppressing regulators like NusG and RfaH that stabilize the closed-clampRNAP conformation, and pause-enhancing regulators like NusA and exit channel nascent RNA structures that stabilize the open clamp RNAP conformation. However, the...

Understanding the mechanism and specificity of substrate binding in the cytochrome P450 (P450) superfamily is an important step toward explaining its key role in drug metabolism, toxicity, xenobiotic degradation, and several biosynthetic pathways. Here we investigate the ligand exit pathways and mechanisms of P450cam (CYP101), P450BM-3 (CYP102), and P450eryF (CYP107A1) by using random expulsion...

Since tubes are widely used for different industrial applications, processing of tubes by the Severe Plastic Deformation (SPD) method has been the target of different attempts. Among these attempts, development of SPD processes for tubes based on Equal Channel Angular Pressing (ECAP) has been more successful. As an illustration, Tube Channel Pressing (TCP) has been presented as an attractive SP...

The ATP-sensitive potassium (K(ATP)) channel controls insulin secretion by coupling glucose metabolism to excitability of the pancreatic beta-cell membrane. The channel comprises four subunits each of Kir6.2 and the sulphonylurea receptor (SUR1), encoded by KCNJ11 and ABCC8, respectively. Mutations in these genes that result in reduced activity or expression of K(ATP) channels lead to enhanced ...

Recently, MIMO (multiple-input multiple-output) systems draw great attention because they offer high spectral efficiency and high reliability, concurrently. For exploiting those gains, channel coefficients need to be known, thus channel training is a crucial part for the performance of MIMO systems. In the first chapter, this work offers a short summary on system models for MIMO systems. The se...

in this paper, the accumulative channel-die compression bounding (accb) method is investigated as a new method of severe plastic deformation to produce nano-crystalline bulk metals on the basis of pressing in a channel mold. aluminum as one of the most usable metal in industry is processed using this method. analyzing the processed samples show that after four passes of accb method, the ultimat...

Profile extrusion is a production technique to make polymer profiles and hollow tubes. At certain distance after the die exit extrudate guided into cooling chamber, where cooled extensively set part dimensions. Uniform in chamber required avoid warpage twisting of due differential shrinkage. The effect on shape residual stresses final product are numerically studied. Two different cases studied...

In this paper, the Accumulative Channel-die Compression Bounding (ACCB) method is investigated as a new method of severe plastic deformation to produce Nano-crystalline bulk metals on the basis of pressing in a channel mold. Aluminum as One of the most usable metal in industry is processed using this method. Analyzing the processed samples show that after four passes of ACCB method, the ultimat...