Monitoring the use of antibiotics is relevant due to the public health impact of microbial resistance, adverse effects, and costs. We present data on the consumption of macrolides, lincosamides, streptogramins and amoxicillin/clavulanate (AMC) between 2007 and 2010 in the in-and outpatient healthcare setting in 10 European countries provided by IMS Health. Antibiotics were classified according ...

BACKGROUND The mechanism of hypoxic pulmonary vasoconstriction (HPV) is still debatable. It has been proposed that reactive oxygen species (ROS) might be involved in HPV. However, there is no special transporter for superoxide anion in the cell membrane and it may release from the cells via anion exchanger. Therefore, the aim of this study was to investigate the interaction of ROS and anion exc...

While little is known about the transport properties of the retinal pigment epithelium (RPE) basal membrane, mechanisms for anion movement across the basal membrane appear to be present (Miller and Steinberg, 1977; Hughes et al., 1984; Miller and Farber, 1984). This work examines the electrophysiological effects of the anion conductance blocker, 4,4'-diisothiocyanostilbene-2,2'-disulfonate (DID...

High endothelial venules (HEV) are specialized postcapillary venules found in lymphoid organs and chronically inflamed tissues that support high levels of lymphocyte extravasation from the blood. One of the major characteristics of HEV endothelial cells (HEVEC) is their capacity to incorporate large amounts of sulfate into sialomucin-type counter-receptors for the lymphocyte homing receptor L-s...

Invoice factoring is a handy tool for developing businesses that face liquidity problems. The main property system needs to fulfill prevent an invoice from being factored twice. Distributed ledger technology suitable implementing the platform register agreements and double-factoring. Several works have been proposed use this factoring. However, current proposals lack in one or several aspects, ...

Electronic health records (EHRs) and medical data are classified as personal in every privacy law, meaning that any related service includes processing such must come with full security, confidentiality, privacy, accountability. Solutions for management, storing it, sharing emerging quickly were significantly boosted by the COVID-19 pandemic created a need to move things online. EHRs make cruci...

4,4'-diisothiocyanostilbene-2,2'-disulfonate (DIDS) appears to block a Cl- conductance in the basal membrane of the chick retinal pigment epithelium (RPE) (Gallemore and Steinberg, 1989). The present paper describes the effect of DIDS, as well as effects of anion movement blockade with other pharmacological agents, on 3 responses that originate as depolarizations of the RPE basal membrane: the ...

This study examined mechanisms of Cl- transport in rat lymphocytes under a variety of conditions. Basal intracellular Cl- concentration ([Cl-]i) was not different between cells assayed in the presence of HCO3- or its absence (HEPES). Removal of external Cl- resulted in a fall in [Cl-]i and a rapid rise in intracellular pH (pH(i)). Both Cl- efflux and the rise in pH(i) were blocked by DIDS or re...

The hepatocyte growth factor receptor (HGFR or c-Met) is a driver of multiple cancer subtypes. While there are several c-Met inhibitors in development, few have been approved for clinical use, warranting the need for continued research and development of c-Met targeting therapeutic modalities. The research presented here demonstrates a particular class of compounds known as isothiocyanatostilbe...

Luminal exposure to concentrated acid, the most accepted physiological stimulus for duodenal bicarbonate secretion (DBS), cannot be used with in vitro preparations due to potential tissue damage. We thus examined whether exposure to PGE(2), a well-characterized physiological duodenal secretagogue, could mimic the effects of acid perfusion. DBS was measured in C57/BL mice by pH-stat/back-titrati...