We investigated the anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex (5.5 or 11 mg/kg) in male Wistar rats (180-300 g, N = 6) and compared it to free diclofenac (5 or 10 mg/kg) and to the combination of diclofenac (5 or 10 mg/kg) and zinc acetate (1.68 or 3.5 mg/kg). The carrageenin-induced paw edema and the cotton pellet-induced granulomatous tissue form...

STUDY OBJECTIVE To determine the optimum time of administration of diclofenac in patients undergoing ambulatory knee arthroscopy: either preoperatively or postoperatively. DESIGN Randomized, double-blind study. SETTING Ambulatory surgical unit in a tertiary referral hospital. PATIENTS 127 ASA physical status I and II patients undergoing ambulatory knee arthroscopy. INTERVENTIONS Patient...

conclusions in the first one hour, diclofenac suppository is able to control the fever more efficient than paracetamol suppositories. results the average rectal temperature in the paracetamol group was 39.6 ± 1.13°c, and 39.82 ± 1.07°c in the diclofenac group (p = 0.37). the average rectal temperature, one hour after the intervention, in the paracetamol and the diclofenac group was 38.39 ± 0.89...

the present study was performed to investigate the effects of long-term intraperitoneal (ip) injection of vitamin b12 and diclofenac in separate and combined treatments on cold and mechanical allodynia in a neuropathic pain model in rats. neuropathic pain was induced by crush injury in right tibial nerve. acetone spray and von frey tests were used to obtain cold and mechanical allodynia respons...

impurities of drug substances may produce some side effects in patient. diclofenac na is a member of non-steroidal anti inflammatory drugs (nsaids) family, which is routinely used by patients for the treatment of rheumatoid arthritis and various pains. to develop a method for the determination of synthetic precursors which could be remained as impurities in raw drug materials, na diclofenac pow...

a simple, precise, rapid and low-cost potentiometric method for diclofenac determination in pharmaceuticals is proposed. a new diclofenac-sensitive electrode was constructed by incorporating the diclofenac ion pair complex with butyl rhodamine b into graphite matrix. the electrode exhibited a linear response over the concentration range of 1 × 10-4 – 5 × 10-2 mol l-1, a detection limit of 3.9×1...

A simple, precise, rapid and low-cost potentiometric method for diclofenac determination in pharmaceuticals is proposed. A new diclofenac-sensitive electrode was constructed by incorporating the diclofenac ion pair complex with butyl rhodamine B into graphite matrix. The electrode exhibited a linear response over the concentration range of 1 × 10-4 – 5 × 10-2 mol L-1, a detection limit of 3.9×1...

The objective of this study was to investigate the potential effect of itraconazole on the pharmacokinetics of diclofenac potassium in beagle dogs after oral coadministration. Five male beagle dogs received a single oral 50 mg dose of diclofenac potassium alone in phase I, and along with a single oral 100 mg dose of itraconazole in phase II. Blood samples obtained for 8.0 hours post dose were a...

PURPOSE To investigate the inhibitory effect of diclofenac sodium on rabbit corneal epithelial cells (RCECs) in vitro and explore its pharmacological mechanism. METHODS The fresh rabbit cornea was cultured to obtain the primary RCECs, and RCECs of passage 2 were used in this research. The cells were divided into experimental groups, the cells in which were incubated with different concentrati...

1. Two female and two male patients with essential hypertension were given dihydralazine plus saline or dihydralazine plus diclofenac intravenously on two separate occasions. The dihydralazine dose (range: 16.2--32.4 mg/2 h) was chosen individually to reduce systolic blood pressure by 20 mmHg from the control value before the investigation; the intravenous diclofenac dose was 75 mg/20 ml of sal...