groups. Group 1 (n = 10) continued to be on food and water ad libitum and served as control. Group 2 (n = 10) received TA (0.3 g/L) of drinking water (5, 6) and food ad libitum for 16 weeks. Group 3 (n = 10) rats received TA (0.3 g/L) and sodium selenite (4 mg/L) of drinking water (7) and food ad libitum for 16 weeks. Group 4 (n = 10) received TA (0.3 g/L) of drinking water for the first 8 week...

The Organisation for Economic Co-operation and Development has completed phase 2 of an international validation program for the rodent uterotrophic bioassay. This portion of phase 2 assessed the reproducibility of the assay with a battery of positive and negative test substances. Positive agonists of the estrogen receptor included the potent reference estrogen 17-ethinyl estradiol (EE), and the...

The interaction of the external donor (propyltrimethoxysilane - PTMS) with titanium-magnesium catalysts (TMCs) containing dibutylphthalate (DBP) as internal donor, which were prepared in different ways, was studied by chemical analysis and infrared diffuse reflectance spectroscopy (DRIFTS). The chemical composition of the catalysts after their interaction with heptane solutions of PTMS, PTMS/Al...

Background: In many developing countries, numerous brands of bottled water and the relatively cheaper counterpart, sachet water, can be found in all cities, towns, and even villages. This study assessed the concentrations of some phthalates and metals in bottled and sachet water sold in Lagos, Nigeria. Methods: Fifteen pieces of plastic bottled water and 15 pieces of sachet water were randomly...

For the last 40 y, substantial evidence has surfaced on the hormone-like effects of environmental chemicals such as pesticides and industrial chemicals in wildlife and humans. The endocrine and reproductive effects of these chemicals are believed to be due to their ability to: (1) mimic the effect of endogenous hormones, (2) antagonize the effect of endogenous hormones, (3) disrupt the synthesi...

Purpose: In vivo studies have focused on the latter stages of the bone metastatic process(osteolysis), whereas little is known about earlier events, e.g., arrival, localization, and initialcolonization. Defining these initial steps may potentially identify the critical points susceptible totherapeutic intervention.Experimental Design: MDA-MB-435 human breast cancer cells enginee...