The thermal reaction of olefins with nitrous oxide was recently put forward as a promising synthetic ketone source. The 1,3-dipolar cycloaddition of N(2)O to the C=C double bond, forming a 4,5-dihydro-[1,2,3]oxadiazole intermediate, was predicted to be the first elementary reaction step. This oxadiazole can subsequently decompose to the desired carbonyl product and N(2)via a hydrogen shift. In ...

A bicyclo[6.1.0]nonyne (BCN)-based cyclooctyne reagent bearing a photocrosslinking diazirine (DAz) group and a biotin affinity handle, BCN-DAz-Biotin, is reported. BCN-DAz-Biotin is capable of simultaneously delivering photocrosslinking and affinity tags to azide-labeled biomolecules, enabling photoactivated capture and enrichment/detection of interacting species in native contexts.

Topographical analysis of the molecular electrostatic potential (MESP) along a reaction path is employed for bringing out sequential electronic reorganizations for 1,3-dipolar cycloadditions of ethyne to fulminic acid as well as diazomethane. A simple and consistent set of rules for portraying electronic mechanisms of chemical reactions using the MESP topography is applied for this purpose. The...

Abstract The paper describes the synthesis of novel strained hydrocarbons based on a diene norbornene series, namely 5-methylene-2-norbornene, using catalytic cyclopropanation with diazomethane. study demonstrated possibility selective solely along endocyclic double bond. physicochemical properties were investigated systematically. These shown to have an advantageous combination high density, l...

starting from 2-(2-pyridyl) imidazole a series of substituted imidazoles (2-5) were prepared. from the reaction of 2-(3-pyridyl) -4-(or 5) nitroimidazole (15) with dimethyl sulfate in alkaline medium 1-methyl-2-(3- pyridy1)-4-nitroimidazole (6,)w as prepared. reaction of compound 15 with diazomethane gave i-methyl-2-(3-pyridy1)-5- nitroimidazol(e7 ) in addition to 6. the antibacterial and antif...