Triazolam and diazepam were compared as oral antianxiety agents in a randomized double-blind, placebo-controlled clinical study of 79 endodontic patients with elevated anxiety regarding endodontic treatment. Patients who scored > or = 10 on the Corah Dental Anxiety Survey received oral formulations of triazolam (0.25 mg), diazepam (5 mg), or placebo. Before, during, and after the endodontic pro...

The actions of diazepam and its p-chloro-derivative Ro 5-4864 were compared on mouse spinal cord and dorsal root ganglion neurons in cell culture. Diazepam enhanced but Ro 5-4864 reduced iontophoretic GABA responses in a concentration-dependent manner. Both diazepam and Ro 5-4864 limited sustained, high frequency repetitive firing of spinal cord neurons but diazepam was more potent. Ro 5-4864 w...

A double-blind study of the effects of diazepam as an adjuvant to propanidid anaesthesia for legal abortion has shown that the incidence of nausea and vomiting was significandy reduced as a result of giving diazepam, and that, in general, the conditions of anaesthesia were more acceptable widi diazepam. The diazepam group had a prolongation of the time to recovery of consciousness but this was ...

Diazepam did not alter the rate or rhythm in III patients with atrial fibrillation. In 3 out of 38 patients with atrial flutter the use of diazepam was followed by an increase in atrioventricular block. Diazepam restored sinus rhythm in I patient with atrial tachycardia (total 7 patients) and in I patient with ventricular tachycardia (total 8 patients). Experimentally in the dog diazepam raised...

Fifteen out of 18 "pink and puffing" patients completed a double-blind, placebo-controlled cross-over trial of diazepam and promethazine for breathlessness and reduced exercise tolerance. Dosages were 25 mg and 125 mg daily, respectively, and each course lasted two weeks. Patients with psychiatric or other major medical histories were excluded. Of the three patients who did not complete the tri...

Specific [3H]phenytoin binding in rat cortical membranes is associated with a micromolar affinity site through which diazepam can exert an enhancing effect. In contrast to diazepam, (+)bicuculline, isoguvacine and pentobarbital inhibited phenytoin binding, while GABA and (-)baclofen had no effect. Decreased phenytoin binding and a loss of the diazepam effect were observed in phospholipase A2-tr...

OBJECTIVE To characterize the effects of diazepam in dogs with behavior problems and to determine whether adverse effects were of sufficient concern to owners to prompt drug discontinuation. DESIGN Cross-sectional study. SAMPLE POPULATION 37 dogs and their owners. PROCEDURES Dogs for which diazepam had been prescribed by the behavior service of a veterinary teaching hospital from July 200...

The role of 5-hydroxytryptamine (serotonin; 5-HT)2C receptors in anxiety and the anxiolytic effects of drugs is well documented. In view of the withdrawal anxiety associated with repeated diazepam intake, the present study concerns the efficacy of 5-HT2C receptors in rats treated with diazepam. Results show that diazepam injections at a dose of 2 mg/kg daily for two weeks increased weekly food ...

Skills related to driving, the ability to discriminate the fusion of flickering light, and hand and foot proprioception, were measured double-blind in 34 healthy volunteers before and after three doses of i.v. diazepam. The effects of diazepam were most harmful to co-ordination. With 0.15 mg/kg, 0.30 mg/kg and 0.45 mg/kg of diazepam the impairment of co-ordinative skills was statistically signi...

Diazepam is a long-acting "classical" benzodiazepine. Diazepam has anticonvulsant properties. Diazepam inhibits acetylcholine release in mouse hippocampal synaptosomes. Viola odorata contains alkaloid, glycoside, saponins, methyl slicylate, mucilage and vitamin C. the objective of present study was to evaluate of sedative and pre-anesthetic effects of Viola odorata linn. extract compared with d...