Background Diastolic dysfunction evaluation may be relevant for early diagnosis of hypertrophic cardiomyopathy (HCM) and subsequent risk assessment. The aim of our study was to assess phase contrast cardiac magnetic resonance (PCCMR) diastolic parameters obtained with a semi-automated method in relation to left ventricular (LV) remodeling and late gadolinium enhancement (LGE) in patients with HCM.

We sought to extract additional physiological information from the time-dependent left ventricular (LV) pressure contour and thereby gain new insights into ventricular function. We used phase plane analysis to characterize high-fidelity pressure data in selected subjects undergoing elective cardiac catheterization. The standard hemodynamic indexes of LV systolic and diastolic function derived f...

Introduction MRI is the accepted gold standard for assessment of left ventricular systolic function; however, no standards are available to assess diastolic function at MRI. E/A and E/ e’ ratios are currently used in echocardiography to evaluate left ventricular diastolic function. Measuring these ratios with phase contrast MRI may provide a complementary approach to assessing left ventricular ...

Introduction MRI is the accepted gold standard for assessment of left ventricular systolic function; however, no standards are available to assess diastolic function at MRI. E/A and E/ e’ ratios are currently used in echocardiography to evaluate left ventricular diastolic function. Measuring these ratios with phase contrast MRI may provide a complementary approach to assessing left ventricular ...

Background Diastolic function is almost exclusively assessed using transthoracic echocardiography (TTE), however velocityencoded phase-contrast imaging permits diastolic evaluation with cardiac magnetic resonance (CMR). However, previous studies have utilized heterogeneous planimetric contour locations to measure mitral valve (MV) inflow velocities and the optimal contour is uncertain. We there...

To elucidate the mechanism of the tension staircase, chick embryonic myocardial cell aggregates were loaded with the fluorescent cytosolic calcium indicator, indol. Fluctuations in indol fluorescence were compared with recordings of cell edge movement during spontaneous beating and during stimulation by intracellular current pulses. Indol-loaded aggregates exhibit fluorescence transients during...

Regenerative discharge of action potentials is induced in mammalian papillary muscles by passage of small depolarizing currents. In this paper, the effects of various extracellular calcium and sodium concentrations and of tetrodotoxin on this phenomenon were studied in guinea pig papillary muscles in a sucrose gap chamber. Phase 4 diastolic depolarization was found to be associated with an incr...

The behavioral significance of changes in the cardiovascular system has been a major source of controversy in psychophysiology. In view of this, it is surprising that so few studies have examined the relationship between cardiac events and electrocortical (EEG) activity in human subjects. In the present study, this relationship was examined by comparing phase, amplitude and frequency of EEG act...

Diastolic phase of cardiac function is associated with lower arterial flow and hence higher concentration of intra arterially injected drug is achieved at the site of injection. It is herein postulated that drugs show higher efficacy when injected during the diastolic phase of cardiac function. It is also postulated that this benefit cannot be achieved when the drug is injected with higher rate...

In order to identify left ventricular diastolic function in patients with betathalassemia major and normal systolic function by noninvasive M-mode and Doppler echocardiography, an analytic study was designed in a university hospital in Sari. We have studied 44 patients (23 men and 21 women), mean age 15.48±2.16 (range 12 to 20) and 43 age and sex matched control subjects. Peak flow velocit...