Gut intraepithelial lymphocytes (IEL) contain two independent T cell receptor a/#+ T cell populations, with different V# repertoires . In DBA/2 mice (Mlsa, IE'), the C1341 and heterodimeric alO CD8+ thymodependent T cell pool shows the same deletion of V#6, 8.1, and 11 + cells as found in peripheral lymphoid organs. In contrast, such deletions are not observed in the pool of IEL bearing homodim...

The gut microbiota impacts many aspects of host biology including immune function. One hypothesis is that microbial communities induce epigenetic changes with accompanying alterations in chromatin accessibility, providing a mechanism that allows a community to have sustained host effects even in the face of its structural or functional variation. We used Assay for Transposase-Accessible Chromat...

BACKGROUND Increased duodenal intraepithelial lymphocytes is a key histological finding in celiac disease. Available studies suggest a wide normal range (10 - 40 intraepithelial lymphocytes /100 epithelial cells, EC). We assessed the normal range of distal duodenal intraepithelial lymphocytes. METHODS Biopsies from the normal-looking distal duodenum from individuals referring for endoscopy fo...

Microscopic colitis (MC) is a chronic inflammatory disease of the colon that presents with chronic, nonbloody watery diarrhea and only few or no endoscopic abnormalities. Histologic examination discriminates lymphocytic (LyC; presence ?20 intraepithelial lymphocytes per 100 surface epithelial cells) collagenous (CC; colonic subepithelial collagen band >10 ?m in diameter).1,2 MC not otherwise sp...

BACKGROUND AND AIMS Post-dysenteric irritable bowel syndrome (PD-IBS) develops in up to 25% of patients following Campylobacter enteritis. Our aim was to define the pathological basis of this subgroup of IBS. METHODS Twenty one patients (group 1) underwent serial rectal biopsy and gut permeability testing following acute Campylobacter enteritis as did 10 PD-IBS patients (group 2) and 12 asymp...

Unrelenting environmental challenges to the gut epithelium place particular demands on the local immune system. In this context, intestinal intraepithelial lymphocytes (IEL) compose a large, highly conserved T cell compartment, hypothesized to provide a first line of defence via cytolysis of dysregulated intestinal epithelial cells (IEC) and cytokine-mediated re-growth of healthy IEC. Here we s...

Olmesartan medoxomil is one of eight marketed Angiotensin II Receptor Blocker for the treatment high blood pressure. Associated Enteropathy has been described in several case reports, subsequently, United states Food and Drug Administrationincluded severe sprue-like enteropathy as an adverse effect Olmesartan. mimics celiac disease clinically pathologically. The pathologic findings are villous ...