OBJECTIVE To determine if improved foot sensitivity to the Semmes-Weinstein 10-g (5.07) monofilament, originally impaired because of diabetic peripheral neuropathy, might be associated with a reduced incidence of new diabetic foot wounds. DESIGN Retrospective cohort study using a health status questionnaire. SUBJECTS Sixty-eight individuals over age 64 with diabetes, diabetic peripheral neu...

BACKGROUND Diabetic neuropathy and idiopathic neuropathy are among the most prevalent neuropathies in human patients. The molecular mechanism underlying pathological changes observed in the affected nerve remains unclear but one candidate molecule, the receptor for advanced glycation end-products (RAGE), has recently gained attention as a potential contributor to neuropathy. Our previous studie...

American Diabetes Association American Academy of Neurology O n 8-10 February 1988, a conference on peripheral neuropathy in diabetes was held in San Antonio, Texas, to review the progress achieved in this field over the past few years. A strong impetus for convening this conference was the recent burst of clinical investigations and trials in diabetic neuropathy and a perception that recent re...

OBJECTIVE To illustrate the prevalence of different types of neuropathy in diabetic patients with diabetic foot. METHODS This is a retrospective study of 229 diabetic foot patients treated at Princess Haya Hospital Hyperbaric Department, Aqaba, Jordan from January 1997 to January 2008, who were found to have different types of neuropathy. Neuropathy diagnosis was reached through investigating...

Objective: Alteration in the basement membrane proteins maybe associated with diabetic neuropathy. Fibronectin is one of the most important components of peripheral nerves basement membrane. In this study we investigated the effects of insulin administration on prevention of alteration in fibronectin contents of sciatic nerve in diabetic rats. Materials and Methods: Twenty-four wistar rats wer...