نتایج جستجو برای: dha

تعداد نتایج: 5264  

Journal: :Journal of immunology 2012
Yan G Zhao Yunqi Wang Zengli Guo Ai-di Gu Han C Dan Albert S Baldwin Weidong Hao Yisong Y Wan

Dihydroartemisinin (DHA) is an important derivative of the herb medicine Artemisia annua L., used in ancient China. DHA is currently used worldwide to treat malaria by killing malaria-causing parasites. In addition to this prominent effect, DHA is thought to regulate cellular functions, such as angiogenesis, tumor cell growth, and immunity. Nonetheless, how DHA affects T cell function remains p...

2016
Yun-Feng Peng Wen-Chao Chen Kang Xiao Lin Xu Lian Wang Xia Wan

The gene encoding phosphopantetheinyl transferase (PPTase), pfaE, a component of the polyketide synthase (PKS) pathway, is crucial for the production of docosahexaenoic acid (DHA, 22:6ω3), along with the other pfa cluster members pfaA, pfaB, pfaC and pfaD. DHA was produced in Escherichia coli by co-expressing pfaABCD from DHA-producing Colwellia psychrerythraea 34H with one of four pfaE genes f...

2017
Zili Zhang Zhen Yao Shifeng Zhao Jiangjuan Shao Anping Chen Feng Zhang Shizhong Zheng

Autophagy and cellular senescence are stress responses essential for homeostasis. Therefore, they may represent new pharmacologic targets for drug development to treat diseases. In this study, we sought to evaluate the effect of dihydroartemisinin (DHA) on senescence of activated hepatic stellate cells (HSCs), and to further elucidate the underlying mechanisms. We found that DHA treatment induc...

Journal: :The Journal of nutrition 2006
Hye-Kyeong Kim Maryanne Della-Fera Ji Lin Clifton A Baile

Docosahexaenoic acid (DHA, C22:6), a (n-3) fatty acid in fish oil, has been shown to decrease body fat and fat accumulation in rodents. We investigated the direct effect of DHA on cell growth, differentiation, apoptosis, and lipolysis using 3T3-L1 adipocytes. Cells were treated with 25-200 mumol/L DHA containing 0.2 mmol/L alpha-tocopherol or bovine serum albumin vehicle as a control. Prolifera...

Journal: :The British journal of nutrition 2010
Saskia A van Goor D A Janneke Dijck-Brouwer Bennard Doornbos Jan Jaap H M Erwich Anne Schaafsma Frits A J Muskiet Mijna Hadders-Algra

DHA and arachidonic acid (AA) are important for neurodevelopment. A traditional neonatal neurological examination and the evaluation of general movement quality are sensitive techniques for assessing neurodevelopment in young infants. Mildly abnormal general movements at 3 months have been associated with a non-optimal current brain condition. We investigated whether supplementation of DHA duri...

2013
M. S. Izquierdo M. Scolamacchia M. Betancor J. Roo M. J. Caballero G. Terova P. E. Witten

DHA deficiency has been related to skeletal malformations in fish, but high DHA levels have produced controversial results that could relate to the oxidative status of fish tissues in the different reports. In the present study, gilthead seabream (Sparus aurata) larvae were fed deficient, adequate or high DHA levels, or high DHA levels supplemented with the antioxidant a-tocopherol. Larvae fed ...

Journal: :The British journal of nutrition 2013
M S Izquierdo M Scolamacchia M Betancor J Roo M J Caballero G Terova P E Witten

DHA deficiency has been related to skeletal malformations in fish, but high DHA levels have produced controversial results that could relate to the oxidative status of fish tissues in the different reports. In the present study, gilthead seabream (Sparus aurata) larvae were fed deficient, adequate or high DHA levels, or high DHA levels supplemented with the antioxidant α-tocopherol. Larvae fed ...

2017
Stephanie L Smith Christopher A Rouse

Docosahexaenoic acid (DHA) is a long chain poly-unsaturated fatty acid (LCPUFA) that has a role in the cognitive and visual development, as well as in the immune function of newborns. Premature infants are typically deficient in DHA for several reasons, to include fetal accretion of DHA that typically occurs during the third trimester. These premature infants are reliant on enteral sources of D...

2017
Hideo Shindou Hideto Koso Junko Sasaki Hiroki Nakanishi Hiroshi Sagara Koh M. Nakagawa Yoshikazu Takahashi Daisuke Hishikawa Yoshiko Iizuka-Hishikawa Fuyuki Tokumasu Hiroshi Noguchi Sumiko Watanabe Takehiko Sasaki Takao Shimizu

Docosahexaenoic acid (DHA) has essential roles in photoreceptor cells in the retina and is therefore crucial to healthy vision. Although the influence of dietary DHA on visual acuity is well known and the retina has an abundance of DHA-containing phospholipids (PL-DHA), the mechanisms associated with DHA's effects on visual function are unknown. We previously identified lysophosphatidic acid ac...

ژورنال: تحقیقات دامپزشکی 2017

زمینه مطالعه: بیماری صرع یک اختلال نورولوژیکی مزمن است که علی‌رغم کشف داروهای موثر، هنوز بیش از30 درصد از بیماران نسبت به داروهای ضد‌‌‌‌صرع رایج مقاوم هستند. هدف: بررسی اثر تجویز حاد دوکوزاهگزانوئیک اسید (DHA) در پیشگیری از بروز مقاومت به داروهای لاموتریجین و فنی‌توئین در مدل تشنجی 6 هرتز در موش سوری نر. روش کار: ابتدا اثرات تجویز داخل بطن مغزی و خوراکی DHA و داروها به‌صورت جداگانه بررسی شد سپس...

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