Following Sir Bruce Keogh's review of 14 NHS Trusts, Buckinghamshire NHS Trust was found to have higher mortality rates than the England average. As part of a series of implementations and investigations to address this, a quality improvement project looking at clinical responses to the deteriorating patients was designed. Buckinghamshire NHS Trust utilises the National Early Warning Score (NEW...

In this paper we consider the problem of scheduling N jobs on a single machine, where the jobs are processed in batches and the processing time of each job is a simple linear increasing function depending on job’s waiting time, which is the time between the start of the processing of the batch to which the job belongs and the start of the processing of the job. Each batch starts from the setup ...

a r t i c l e i n f o This paper expands an inventory model for deteriorating items with stock-dependent demand. This model provides time varying backlogging rate as well as time varying deterioration rate. The aim of this model is to determine the optimal cycle length of each product such that the expected total cost (holding, shortage, ordering, deterioration and opportunity cost) is minimize...

In a real manufacturing system, a machine may need multiple maintenance activities to improve its production efficiency due to the effects of aging or deteriorating. This paper considers scheduling with aging or deteriorating effects and deteriorating maintenance activities simultaneously on a single machine. We assume that the machine may be subject to several maintenance activities during the...

Bronchial thermoplasty is a novel procedure for patients with severe asthma showing a stable lung function. We herein report two cases with a deteriorating lung function. The lung function tended to improve in one case, while the other case discontinued mepolizumab medication after the procedure. Treatment was performed safely under general anesthesia in both cases. The use of bronchial thermop...

The tremendous development of location-based services and mobile devices has led to an increase in location databases. Through the data mining process, valuable information can be discovered from such location databases. However, the malicious data miner or attackers may also extract private and sensitive information about the user, and this can create threats against the user location privacy....

The problem of scheduling the production of new and recoverable defective items of the same product manufactured on the same facility is studied. Items are processed in batches. Each batch comprises two sub-batches processed consecutively. In the first subbatch, all the items are newly manufactured. Some of them are of the required good quality and some are defective. The defective items are re...

Risk stratification in advanced heart failure (HF) is crucial for the individualization of therapeutic strategy, in particular for heart transplantation and ventricular assist device implantation. We tested the hypothesis that cardiac gene expression profiling can distinguish between HF patients with different disease severity. We obtained tissue samples from both left (LV) and right (RV) ventr...

Optimal pricing and marketing planning plays an essential role in production decisions on deteriorating items. This paper presents a mathematical model for a three-level supply chain, which includes one producer, one distributor and one retailer. The proposed study considers the production of a deteriorating item where demand is influenced by price, marketing expenditure, quality of product and...