Dear editor: 1 few years after coming to the market, the first generation of oral contraceptive pills (OCPs) were linked to significant risk of venous thromboembolism (VTE). This increased risk was blamed on the presence of the estrogen-like compounds in these agents. Therefore, the efforts were initiated to decrease the VTE risk of OCPs by lowering the delivered estrogen content by adding prog...

marvelon®, a combined oral contraceptive, contains 30 μg ethinyl estradiol (ee) and 150 μg desogestrel (de), and has been shown to be a well-tolerated and effective combination that provides high contraceptive reliability and good cycle control. however, its efficacy has not been yet evaluated among iranian women. thus, the study aimed to determine the effect of oral contraceptive pill on treat...

Madam I look forward to the arrival of the Journal. It is always a good read, full of relevant and practical information – much more ‘user-friendly’ than most journals I receive these days. July’s edition seemed particularly interesting with a number of interesting articles. However, my interest was quickly replaced by irritation. There is a lot to be said for evidencebased medicine (EBM) and i...

Madam I look forward to the arrival of the Journal. It is always a good read, full of relevant and practical information – much more ‘user-friendly’ than most journals I receive these days. July’s edition seemed particularly interesting with a number of interesting articles. However, my interest was quickly replaced by irritation. There is a lot to be said for evidencebased medicine (EBM) and i...

The influence of gender on serum concentrations of growth hormone (GH) and 12 other endocrine analytes was investigated in sera drawn from 291 healthy medical students in the ambulatory state in the morning, after fasting overnight. GH was measured with a sensitive noncompetitive fluoroimmunoassay. The median GH value was 80-fold higher in women 21-26 years old than in age-matched men (14.4 vs ...

This study compared the impact on carbohydrate metabolism of two combinedoral contraceptives (COCs). This open-label, single-center trial enrolled participants for a total of 15 cycles. Thirty-six women were randomized to receive either 20 microg ethinyl estradiol (EE) and 75 microg gestodene (GSD) or 20 microg ethinyl estradiol and 150 microg desogestrel (DSG) daily for 21 days out of 28. A gl...

A new RP-HPLC method was developed for selective and simultaneous determination of of Desogestrel and Ethinyl Estradiol Tablets. The chromatographic separation was achieved on a Zorbax SB C-18, 4.6 x 250mm, and 5μ column. The gradient LC method employs solutions A and B as mobile phase. The solution A milliQ water and acetonitrile in the ratio of 90:10 and degas and solution B contains a mixtur...

Evidence There are no long-term RCTs, which leaves cohort and case-control studies as evidence. • The Society of Obstetricians and Gynaecologists of Canada1 and others2 have stated that evidence about the risk of VTE with different progestins is inconclusive owing to mixed results and a high risk of bias. • Some studies found no increased VTE risk with drospirenone3 or a transdermal patch.4 • S...

Oral contraceptives (OC) are, or perhaps more correctly, were, until recently, being taken by approximately 6.5 million women worldwide, which corresponds to approximately 6% of all women of reproductive age. OCs have been available since the early 1960s and there is substantial evidence to suggest that no single medication has had such a profound impact on our reproduction and social life as t...