BACKGROUND In vitro, cold-induced injury is an important contributor to renal tubular cell damage. It is mediated by iron-dependent formation of reactive oxygen species and can be prevented by iron chelation. We studied whether iron chelators can prevent cold-induced damage in the isolated perfused rat kidney (IPK) model both after cold perfusion (CP) and after cold storage (CS). We hypothesize...

abstract objective cardiac dysfunction is a major cause of death in patients with beta thalassemia. in these patients, repeated blood transfusion, ineffective erythropoiesis and increased gastrointestinal iron absorption lead to iron overload in the body and this induced heart failure. left ventricular ejection fraction was measured in major beta thalassemia (β-th) patients to detect the relati...

background: major beta thalassemia is the most common inherited anemia with high prevalence in iran and hearing loss is one of its side effects. the present study aimed to determine the hearing status of patients with major thalassemia and its relationship with serum ferritin level, period of blood transfusion and dessfroxamin administration. methods: this descriptive-analytic study was perform...

The interest in zirconium-89 (89Zr) as a positron-emitting radionuclide has grown considerably over the last decade due to its standardized production, long half-life of 78.2 h, favorable decay characteristics for positron emission tomography (PET) imaging and its successful use in a variety of clinical and preclinical applications. However, to be utilized effectively in PET applications it mus...

INJURY to the cornea with an iron-containing foreign body usually leaves a rust ring. Most surgeons advise complete removal of any rust, but this often causes considerable trauma to the already injured cornea. Desferrioxamine ("Desferal", Ciba Laboratories) is an iron-free compound isolated from a strain of Streptomycespilosus, which binds ferric ions to form an octahedral complex ferrioxamine....

In several cell types, apoptosis is associated with intracellular acidification and activation of a pH-dependent endonuclease. We have examined the effect of acidic pH on the DNA of permeabilized human fibroblasts, and observed cleavage of DNA into high-molecular-mass fragments. This pH-dependent DNA breakage was modulated by temperature, the presence of histones and diethyl pyrocarbonate. Supe...