The established agent leuprorelin acetate can be administered in combination with a novel biodegradable polymer matrix (Atrigel delivery system) to reduce testosterone levels in men with advanced hormone-dependent prostate cancer. Since 2007, this new formulation is available as a 6-month depot (Eligard 45 mg). The results of a recent non-interventional study, investigating the efficacy and saf...

The multi-depot fleet size and mix vehicle routing problem, also known as the multi-depot routing with heterogeneous vehicles, is investigated. A mathematical formulation is given and lower as well as upper bounds are produced using a three hour execution time of CPLEX. An efficient implementation of variable neighborhood search that incorporates new features in addition to the adaptation of se...

In this paper, a variant of the Traveling Salesman Problem with Time Windows is considered, which consists in minimizing the sum of travel durations between a depot and several customer locations. Two mixed integer linear programming formulations are presented for this problem: a classical arc flow model and a sequential assignment model. Several polyhedral results are provided for the second f...

This paper considers the problem of finding a route and schedule for a vehicle starting from a depot, visiting a set of customers and returning to the depot, in a time-dependent network where the objective is to minimize the greenhouse gas emissions. In this formulation, the speeds of the vehicle as well as the routes chosen are decision variables subject to limits determined by the level of co...

OBJECTIVE Depot GnRH agonists are commonly used in the treatment of central precocious puberty (CPP). The triptorelin 11.25 mg 3-month depot, currently used in adult indications, had not previously been evaluated in CPP. DESIGN This was a multicenter, open-label, 12 month trial conducted in 64 CPP children (54 girls and 10 boys), treated quarterly. METHODS Children with a clinical onset of ...

Consider a graph G=(V,A), where V ={1,2,..,n} and A={(i,j): i,j=1,..,n, i ≠ j}. The TimeDependent Travelling Salesman problem (TDTSP) is to find a minimum cost Hamiltonian circuit, starting and ending on node 1, where arc costs depend on its position in the tour. Thus, to each arc (i,j) in A and each possible position h of the arc in the tour we associate a cost h ij c . Clearly, an arc (1,j) l...

In this paper we model and solve the multi-depot fleet size and mix vehicle routing problem (MDFSMVRP). This problem extends the multi-depot vehicle routing problem and the fleet size and mix vehicle routing problem, two logistics problems that have been extensively studied for many decades. This difficult transportation problem combines complex assignment and routing decisions under the object...

BACKGROUND The ACTH stimulation test is used to evaluate the adrenocortical reserve. Recently, the availability of the synthetic ACTH formulation was limited, causing major problems in clinical practice. OBJECTIVES The objective of this study was to evaluate poststimulation peak cortisol concentrations and the duration of the stimulatory effect of a depot ACTH preparation in dogs. ANIMALS T...