A common psychopharmacology between pain and depression suggests that compounds inhibiting the reuptake of serotonin and/or noradrenaline are likely to produce relief from chronic pain. Indeed tricyclic antidepressants have been a standard treatment of chronic pain for many years. In spite of their improved tolerance, selective serotonin reuptake inhibitors do not appear to be particularly effe...

Bruxism affects roughly 5-20% of the adult population. It can be defined as a repetitive jaw-muscle activity characterized by clenching or grinding teeth and occur during sleep-related disorder daytime. irreversibly damage dentition restorations also lead to temporomandibular joint disorders headaches.

CONTEXT Depression among youth is a disabling condition that is associated with serious long-term morbidities and suicide. OBJECTIVE To assess the health effects of routine primary care screening for major depressive disorder among children and adolescents aged 7 to 18 years. METHODS Medline, the Cochrane Central Registry of Controlled Trials, PsycInfo, the Cochrane Database of Systematic R...

OBJECTIVE To estimate the risk of major congenital anomalies after exposure to selective serotonin reuptake inhibitors during pregnancy. METHODS A retrospective cohort study based on national population-based registers (years 1996-2006) of births, congenital anomalies, and terminations of pregnancy because of severe fetal anomalies (maintained by National Institute for Health and Welfare, sou...

Citation: Fried EI, Boschloo L, van Borkulo CD, Schoevers RA, Romeijn J-W, Wichers M, de Jonge P, Nesse RM, Tuerlinckx F and Borsboom D (2015) Commentary: “Consistent superiority of selective serotonin reuptake inhibitors over placebo in reducing depressed mood in patients with major depression”. Front. Psychiatry 6:117. doi: 10.3389/fpsyt.2015.00117 Commentary: “Consistent superiority of selec...

Serotonin is a naturally occurring “messenger” protein that is found primarily in the gastrointestinal system, certain blood cells (platelets) and the central nervous system (brain and brain stem). Abnormal activity of this messenger protein has been implicated in both migraine and depression, and medications that modify serotonin can be effective in treating both disorders. Such medications in...

We review the cardiovascular effects of newer antidepressants. Although further studies are warranted, the safety of the selective serotonin reuptake inhibitors and the serotonin norepinephrine reuptake inhibitors on patients with comorbid cardiac conditions is impressive. Newer antidepressants should be considered as first-line agents for the treatment of depression in patients with and withou...