Apart from clinical, histological and biochemical indices, genomics are now being employed to unravel the pathogenetic mechanisms in the disease progression of IgA nephritis (IgAN). The results of angiotensin converting enzyme (ACE) gene polymorphism have been controversial. Those patients with the DD genotype seem to have a poorer prognosis. However, with high dose angiotensin receptor blocker...

Deoxyribo Nucleic Acid (DNA) microarray technology allows us to generate thousands of gene expression in a single chip. Analyzing gene expression data plays vital role in understanding diseases and discovering medicines. Classification of cancer based on gene expression data is a promising research area in the field of bioinformatics and data mining. All genes do not contribute for efficient cl...

An ab initio method is used in a two state model to calculate consistent relative enthalpies and free energies for the stacking of nucleic acid bases in deoxyribose dinucleotides and the Watson-Crick hydrogen bonding interactions between mononucleotides when uncharged and singly charged. Favorable free energy changes are determined for the formation of dimers between mononucleotides by Watson-C...